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Arch Environ Health

Title:		"Passive smoking, excretion of metabolites, and health effects: results of the Leipzig's Allergy Risk Study (LARS)"
Author(s):		Rolle-Kampczyk UE; Rehwagen M; Diez U; Richter M; Herbarth O; Borte M;
Address:		"Institute for Environmental Hygiene and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany"
Journal Title:		Arch Environ Health
Year:		2002
Volume:		57
Issue:		4
Page Number:		326 - 331
DOI:		10.1080/00039890209601416
ISSN/ISBN:		0003-9896 (Print) 0003-9896 (Linking)
Abstract:		"Over a 5-yr period, the Leipzig's Allergy Risk Study (LARS) investigated the influence of typical indoor-contaminant burdens on the development of allergies and upper respiratory tract infections in allergy-prone children. Typical indoor volatile organic compounds (VOCs) and excretion of certain VOC metabolites in urine were measured in children 3 yr of age. Data analyses were based on parent-completed questionnaires, exposure measurements, and medical examinations. Evaluation of passive smoking was of special interest. Generally, residences with a high burden of passive smoking had higher benzene concentrations than residences inhabited by nonsmokers. Obstructive bronchitis was observed more frequently in children exposed to increased concentrations of benzene, as well as toluene, styrene, and m,p-xylene. In addition, atopic symptoms were associated with excretion of certain VOC metabolites. For example, the authors found an association between eczema and exposure to toluene and between eczema and increased excretion of the toluene metabolite S-benzylmercapturic acid. The results suggest that if an association with certain health effects is to be demonstrated, evaluation of external exposures should be supplemented with evaluations of internal exposure"
Keywords:		"Child Welfare Child, Preschool Cohort Studies *Environmental Exposure Female Health Status Humans Hypersensitivity/*etiology Male Organic Chemicals/adverse effects Respiratory Tract Infections/*etiology Risk Assessment Tobacco Smoke Pollution/*adverse eff;"
Notes:		"MedlineRolle-Kampczyk, Ulrike E Rehwagen, Martina Diez, Ulrike Richter, Matthias Herbarth, Olf Borte, Michael eng Research Support, Non-U.S. Gov't 2003/01/18 Arch Environ Health. 2002 Jul-Aug; 57(4):326-31. doi: 10.1080/00039890209601416"