| Title: | Signal transduction by MAP kinase cascades in budding yeast |
| Author(s): | Posas F; Takekawa M; Saito H; |
| Address: | "Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street,Boston, MA 02115, USA" |
| DOI: | 10.1016/s1369-5274(98)80008-8 |
| ISSN/ISBN: | 1369-5274 (Print) 1369-5274 (Linking) |
| Abstract: | "Budding yeast contain at least four distinct MAPK (mitogen activated protein kinase) cascades that transduce a variety of intracellular signals: mating-pheromone response, pseudohyphal/invasive growth, cell wall integrity, and high osmolarity adaptation. Although each MAPK cascade contains a conserved set of three protein kinases, the upstream activation mechanisms for these cascades are diverse, including a trimeric G protein, monomeric small G proteins, and a prokaryotic-like two-component system. Recently, it became apparent that there is extensive sharing of signaling elements among the MAPK pathways; however, little undesirable cross-talk occurs between various cascades. The formation of multi-protein signaling complexes is probably centrally important for this insulation of individual MAPK cascades" |
| Keywords: | "Calcium-Calmodulin-Dependent Protein Kinases/genetics/*metabolism Fungal Proteins/genetics/metabolism *Gene Expression Regulation, Fungal Mating Factor Osmolar Concentration Peptides/metabolism Phosphoprotein Phosphatases/metabolism Protein Kinase C/metab;" |
| Notes: | "MedlinePosas, F Takekawa, M Saito, H eng Review England 1999/03/06 Curr Opin Microbiol. 1998 Apr; 1(2):175-82. doi: 10.1016/s1369-5274(98)80008-8" |
