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Molecules

Title:		Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review
Author(s):		Pereira JAM; Porto-Figueira P; Taware R; Sukul P; Rapole S; Camara JS;
Address:		"CQM-Centro de Quimica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal. Proteomics Lab, National Centre for Cell Science (NCCS), Ganeshkhind Road, SPPU Campus, Pune 411007, India. Department of Anaesthesiology and Intensive Care Medicine, Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Rostock University Medical Centre, 18057 Rostock, Germany. Faculdade de Ciencias Exatas e da Engenharia, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"
Journal Title:		Molecules
Year:		2020
Volume:		20200707
Issue:		13
Page Number:		-
DOI:		10.3390/molecules25133098
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Human VOCs are released from biomatrices such as saliva, urine, skin emanations and exhaled breath and are derived from many metabolic pathways. In this review, the potential of VOCs present in saliva will be explored as a monitoring tool for several oral diseases, including gingivitis and periodontal disease, dental caries, and oral cancer. Moreover, the analytical state-of-the-art for salivary volatomics, e.g., the most common extraction techniques along with the current challenges and future perspectives will be addressed unequivocally"
Keywords:		"Biomarkers, Tumor/*metabolism Dental Caries/*metabolism Humans Mouth Neoplasms/*metabolism Periodontal Diseases/*metabolism Saliva/*metabolism Volatile Organic Compounds/*metabolism analytical platforms biomarkers oral diseases (ODs) saliva volatile organ;"
Notes:		"MedlinePereira, Jorge A M Porto-Figueira, Priscilla Taware, Ravindra Sukul, Pritam Rapole, Srikanth Camara, Jose S eng UIDB/00674/2020/Fundacao para a Ciencia e a Tecnologia/ M1420-01-0145-FEDER-000005/ARDITI-Agencia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao/ SFRH/BD/129630/2017/Fundacao para a Ciencia e a Tecnologia/ M1420 - 09-5369-FSE-000001/ARDITI-Agencia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao/ Inno-INDIGO NCDs-CAPomics/Era net/ Review Switzerland 2020/07/11 Molecules. 2020 Jul 7; 25(13):3098. doi: 10.3390/molecules25133098"