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Korean J Physiol Pharmacol

Title:		Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
Author(s):		Park JH; Ha H;
Address:		"Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea"
Journal Title:		Korean J Physiol Pharmacol
Year:		2015
Volume:		20150430
Issue:		3
Page Number:		269 - 274
DOI:		10.4196/kjpp.2015.19.3.269
ISSN/ISBN:		1226-4512 (Print) 2093-3827 (Electronic) 1226-4512 (Linking)
Abstract:		"Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappaB (NF-kappaB) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-kappaB signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases"
Keywords:		Aging Hep G2 cells Inflammation Liver Pheromones;Animals;
Notes:		"PubMed-not-MEDLINEPark, Jong Hee Ha, Hunjoo eng Korea (South) 2015/05/09 Korean J Physiol Pharmacol. 2015 May; 19(3):269-74. doi: 10.4196/kjpp.2015.19.3.269. Epub 2015 Apr 30"