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Clin Chim Acta

Title:		The role of metabolomics in neonatal and pediatric laboratory medicine
Author(s):		Mussap M; Antonucci R; Noto A; Fanos V;
Address:		"Laboratory Medicine Service, IRCCS AOU San Martino-IST, University-Hospital, National Institute for Cancer Research, Genova, Italy"
Journal Title:		Clin Chim Acta
Year:		2013
Volume:		20130911
Issue:
Page Number:		127 - 138
DOI:		10.1016/j.cca.2013.08.020
ISSN/ISBN:		1873-3492 (Electronic) 0009-8981 (Linking)
Abstract:		"Metabolomics consists of the quantitative analysis of a large number of low molecular mass metabolites involving substrates or products in metabolic pathways existing in all living systems. The analysis of the metabolic profile detectable in a human biological fluid allows to instantly identify changes in the composition of endogenous and exogenous metabolites caused by the interaction between specific physiopathological states, gene expression, and environment. In pediatrics and neonatology, metabolomics offers new encouraging perspectives for the improvement of critically ill patient outcome, for the early recognition of metabolic profiles associated with the development of diseases in the adult life, and for delivery of individualized medicine. In this view, nutrimetabolomics, based on the recognition of specific cluster of metabolites associated with nutrition and pharmacometabolomics, based on the capacity to personalize drug therapy by analyzing metabolic modifications due to therapeutic treatment may open new frontiers in the prevention and in the treatment of pediatric and neonatal diseases. This review summarizes the most relevant results published in the literature on the application of metabolomics in pediatric and neonatal clinical settings. However, there is the urgent need to standardize physiological and preanalytical variables, analytical methods, data processing, and result presentation, before establishing the definitive clinical value of results"
Keywords:		"Child Humans Infant, Newborn Medical Laboratory Science/*methods Metabolome *Metabolomics (1)h nmr Adma Adp Aga Akd Aki Amp Balf Bmi Ce Ckd Cld Csf Dims Elbw Esrd Ftir Fourier transform infrared spectroscopy Gc-ms Hie Hmdb Hva-so(4) Icu Iq Iugr Lbw Lc-ms;"
Notes:		"MedlineMussap, Michele Antonucci, Roberto Noto, Antonio Fanos, Vassilios eng Review Netherlands 2013/09/17 Clin Chim Acta. 2013 Nov 15; 426:127-38. doi: 10.1016/j.cca.2013.08.020. Epub 2013 Sep 11"