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Respir Med

Title:		Urinary volatile organic compound metabolites and reduced lung function in U.S. adults
Author(s):		Mendy A; Burcham S; Merianos AL; Mersha TB; Mahabee-Gittens EM; Chen A; Yolton K;
Address:		"Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: angelico.mendy@uc.edu. Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA. School of Human Services, University of Cincinnati, Cincinnati, OH, USA. Division of Asthma Research, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA"
Journal Title:		Respir Med
Year:		2022
Volume:		20221110
Issue:
Page Number:		107053 -
DOI:		10.1016/j.rmed.2022.107053
ISSN/ISBN:		1532-3064 (Electronic) 0954-6111 (Print) 0954-6111 (Linking)
Abstract:		"BACKGROUND: Volatile organic compounds (VOCs) are associated with adverse respiratory outcomes at high occupational exposures. However, whether exposure levels found in the general population have similar effects is unknown. METHODS: We analyzed data on 1342 adult participants in the 2011-2012 National Health and Nutrition Examination Survey aged >/=18 years old who had urinary VOC metabolites and spirometry measurements available. Linear regression models adjusting for covariates were fitted to estimate the associations of VOC exposures levels and spirometry outcomes, while accounting for survey design and sampling weights to generate nationally representative estimates. RESULTS: The urinary metabolites for xylene, acrylamide, acrolein, 1,3-butadiene, cyanide, toluene, 1-bromopropane, acrylonitrile, propylene oxide, styrene, ethylbenzene, and crotonaldehyde in our analysis were all detected in >75% of participants. Forced expiratory volume in 1 s (FEV(1)) to forced vital capacity (FVC) ratio % was lower with urinary metabolites of acrylamide (beta: -2.65, 95% CI: -4.32, -0.98), acrylonitrile (beta: -1.02, 95% CI: -2.01, -0.03), and styrene (beta: -3.13, 95% CI: -5.35, -0.90). FEV(1)% predicted was lower with the urinary metabolites of acrolein (beta: -7.77, 95% CI: -13.29, -2.25), acrylonitrile (beta: -2.05, 95% CI: -3.77, -0.34), propylene oxide (beta: -2.90, 95% CI: -5.50, -0.32), and styrene (beta: -4.41, 95% CI: -6.97, -1.85). CONCLUSIONS: This is the first study of a representative sample of the U.S. adult population to reveal associations of acrylonitrile, propylene oxide, and styrene urinary metabolites with reduced lung function at non-occupational exposures. Results also support previous evidence of acrylamide and acrolein's association with adverse respiratory outcomes"
Keywords:		Adult Humans Adolescent *Volatile Organic Compounds Nutrition Surveys Acrylamide Styrene Lung/metabolism Lung function Spirometry Urinary metabolites Volatile organic compounds;
Notes:		"MedlineMendy, Angelico Burcham, Sara Merianos, Ashley L Mersha, Tesfaye B Mahabee-Gittens, E Melinda Chen, Aimin Yolton, Kimberley eng P30 ES006096/ES/NIEHS NIH HHS/ R01 ES034049/ES/NIEHS NIH HHS/ R01 HL132344/HL/NHLBI NIH HHS/ R21 ES032161/ES/NIEHS NIH HHS/ K01 DA044313/DA/NIDA NIH HHS/ R01 ES027815/ES/NIEHS NIH HHS/ R01 HG011411/HG/NHGRI NIH HHS/ Research Support, N.I.H., Extramural England 2022/11/19 Respir Med. 2022 Dec; 205:107053. doi: 10.1016/j.rmed.2022.107053. Epub 2022 Nov 10"