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EMBO J

Title:		"The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast"
Author(s):		McLeod M; Stein M; Beach D;
Address:
Journal Title:		EMBO J
Year:		1987
Volume:		6
Issue:		3
Page Number:		729 - 736
DOI:		10.1002/j.1460-2075.1987.tb04814.x
ISSN/ISBN:		0261-4189 (Print) 1460-2075 (Electronic) 0261-4189 (Linking)
Abstract:		"In fission yeast the ability to undergo meiosis and sporulation is conferred by the matP+ and matM+ genes of the mating-type locus. Inactivation of ran1+, a negative regulator of meiosis, is thought to be an essential step in meiotic initiation. We have isolated a further meiotic control gene mei3+, and have shown the following: a null allele of mei3 totally inhibits meiosis; the mei3+ RNA transcript and its translational product are expressed only in matP+/matM+ diploids entering meiosis; forced expression of mei3+ in vegetative cells provokes haploid meiosis and sporulation. We suggest that the product of mei3+ gene, a protein of 21 kd, initiates meiosis by inactivating ran1+"
Keywords:		"Alleles Amino Acid Sequence Base Sequence DNA Restriction Enzymes Escherichia coli/genetics Fungal Proteins/*genetics *Genes *Genes, Fungal *Genes, Mating Type, Fungal Genetic Vectors Mating Factor Meiosis Molecular Sequence Data Peptides/*genetics Protei;"
Notes:		"MedlineMcLeod, M Stein, M Beach, D eng GM34517-01/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1987/03/01 EMBO J. 1987 Mar; 6(3):729-36. doi: 10.1002/j.1460-2075.1987.tb04814.x"