| Title: | Relationships between levels of volatile organic compounds in air and blood from the general population |
| Author(s): | Lin YS; Egeghy PP; Rappaport SM; |
| Address: | "Department of Environmental and Occupational Health, School of Public Health, University of North Texas Health Science Center, Fort Worth, Texas, USA" |
| Journal Title: | J Expo Sci Environ Epidemiol |
| ISSN/ISBN: | 1559-064X (Electronic) 1559-0631 (Linking) |
| Abstract: | "The relationships between levels of volatile organic compounds (VOCs) in blood and air have not been well characterized in the general population where exposure concentrations are generally at parts per billion levels. This study investigates relationships between the levels of nine VOCs, namely, benzene, chloroform, 1,4-dichlorobenzene, ethylbenzene, methyl tert-butyl ether (MTBE), tetrachloroethene, toluene, and m-/p- and o-xylene, in blood and air from a stratified random sample of the general US population. We used data collected from 354 participants, including 89 smokers and 265 nonsmokers, aged 20-59 years, who provided samples of blood and air in the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Demographic and physiological characteristics were obtained from self-reported information; smoking status was determined from levels of serum cotinine. Multiple linear regression models were used to investigate the relationships between VOC levels in air and blood, while adjusting for effects of smoking and demographic factors. Although levels of VOCs in blood were positively correlated with the corresponding air levels, the strength of association (R(2)) varied from 0.02 (ethylbenzene) to 0.68 (1,4-DCB). Also the blood-air relationships of benzene, toluene, ethylbenzene, and the xylenes (BTEX) were influenced by smoking, exposure-smoking interactions, and by gender, age, and BMI, whereas those of the other VOCs were not. Interestingly, the particular exposure-smoking interaction for benzene was different from those for toluene, ethylbenzene, and the xylenes. Whereas smokers retained more benzene in their blood at increasing exposure levels, they retained less toluene, ethylbenzene, and xylenes at increasing exposure levels. Investigators should consider interaction effects of exposure levels and smoking when exploring the blood-air relationships of the BTEX compounds in the general population" |
| Keywords: | "Adult Air Pollutants/*analysis/*blood Confounding Factors, Epidemiologic Environmental Exposure/*analysis Environmental Monitoring/methods Female Humans Hydrocarbons, Aromatic/*analysis/*blood Linear Models Male Middle Aged Nutrition Surveys Organic Chemi;" |
| Notes: | "MedlineLin, Y S Egeghy, P P Rappaport, S M eng Research Support, Non-U.S. Gov't 2007/12/07 J Expo Sci Environ Epidemiol. 2008 Jul; 18(4):421-9. doi: 10.1038/sj.jes.7500635. Epub 2007 Dec 5" |
