| Title: | Aggression is associated with aerobic glycolysis in the honey bee brain(1) |
| Author(s): | Chandrasekaran S; Rittschof CC; Djukovic D; Gu H; Raftery D; Price ND; Robinson GE; |
| Address: | "Institute for Systems Biology, Seattle, WA; Center for Biophysics and Computational Biology" |
| ISSN/ISBN: | 1601-183X (Electronic) 1601-1848 (Print) 1601-183X (Linking) |
| Abstract: | "Aerobic glycolysis involves increased glycolysis and decreased oxidative catabolism of glucose even in the presence of an ample oxygen supply. Aerobic glycolysis, a common metabolic pattern in cancer cells, was recently discovered in both the healthy and diseased human brain, but its functional significance is not understood. This metabolic pattern in the brain is surprising because it results in decreased efficiency of adenosine triphosphate (ATP) production in a tissue with high energetic demands. We report that highly aggressive honey bees (Apis mellifera) show a brain transcriptomic and metabolic state consistent with aerobic glycolysis, i.e. increased glycolysis in combination with decreased oxidative phosphorylation. Furthermore, exposure to alarm pheromone, which provokes aggression, causes a metabolic shift to aerobic glycolysis in the bee brain. We hypothesize that this metabolic state, which is associated with altered neurotransmitter levels, increased glycolytically derived ATP and a reduced cellular redox state, may lead to increased neuronal excitability and oxidative stress in the brain. Our analysis provides evidence for a robust, distinct and persistent brain metabolic response to aggression-inducing social cues. This finding for the first time associates aerobic glycolysis with naturally occurring behavioral plasticity, which has important implications for understanding both healthy and diseased brain function" |
| Keywords: | "Adenosine Triphosphate/metabolism Aggression/*physiology Animals Bees *Behavior, Animal Brain/*metabolism Glucose/metabolism Glycolysis/*physiology Microarray Analysis/methods Pheromones Aerobic glycolysis aggression brain metabolism metabolomics neurogen;" |
| Notes: | "MedlineChandrasekaran, S Rittschof, C C Djukovic, D Gu, H Raftery, D Price, N D Robinson, G E eng 1U01AG046139-01/AG/NIA NIH HHS/ P50 GM076547/GM/NIGMS NIH HHS/ Howard Hughes Medical Institute/ U01 AG046139/AG/NIA NIH HHS/ 2P50GM076547/GM/NIGMS NIH HHS/ DP1 OD006416/OD/NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2015/02/03 Genes Brain Behav. 2015 Feb; 14(2):158-66. doi: 10.1111/gbb.12201. Epub 2015 Mar 5" |
