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J Steroid Biochem Mol Biol

Title:		Resveratrol reverses Palmitic Acid-induced cow neutrophils apoptosis through shifting glucose metabolism into lipid metabolism via Cav-1/ CPT 1-mediated FAO enhancement
Author(s):		Li Y; Zhang Y; Deng Q; Mao J; Jia Z; Tang M; Zhang Y; Zhao J; Chen J; Wang Y; Feng Z; Wang X; Du L;
Address:		"College of Animal Science and Technology, Inner Mongolia MINZU University, Tongliao 028000, Inner Mongolia Autonomous Region, China. College of Animal Science and Technology, Inner Mongolia MINZU University, Tongliao 028000, Inner Mongolia Autonomous Region, China; Inner Mongolia MINZU University Key Laboratory for Prevention and Control of Herbivorous Livestock Perinatal Diseases, Tongliao 028000, Inner Mongolia Autonomous Region, China. College of Animal Science and Technology, Inner Mongolia MINZU University, Tongliao 028000, Inner Mongolia Autonomous Region, China; Inner Mongolia MINZU University Key Laboratory for Prevention and Control of Herbivorous Livestock Perinatal Diseases, Tongliao 028000, Inner Mongolia Autonomous Region, China. Electronic address: duliyin2016@163.com"
Journal Title:		J Steroid Biochem Mol Biol
Year:		2023
Volume:		20230715
Issue:
Page Number:		106363 -
DOI:		10.1016/j.jsbmb.2023.106363
ISSN/ISBN:		1879-1220 (Electronic) 0960-0760 (Linking)
Abstract:		"Elevated plasma nonesterified fatty acids (NEFAs) affect neutrophils function and longevity during the periparturient period in dairy cows. Previous research has shown that resveratrol (RSV) may protect cell viability from NEFA-induced damage by regulating energy metabolism. However, it is unclear whether RSV has a protective effect on palmitic acid (PA)-treated neutrophils. The aim of this study was to investigate the molecular regulatory mechanism of the protective effect of RSV on neutrophils. The results showed that treatment with high concentrations of RSV (50 muM, 100 muM) maintained neutrophils activity by inhibiting neutrophils apoptosis (P < 0.05). Further analysis showed that high concentrations of RSV enhanced fatty acid oxidation (FAO) to produce ATP by promoting the expression of CAV1, ACSL-1 and CPT1 (P < 0. 05) while inhibiting glycolysis by suppressing PFK1 activity (P < 0. 05) and reducing glucose transport-related protein (GLUT1/GLUT4) expression by inhibiting glucose uptake (P < 0.05). These results suggest that RSV protects neutrophils from PA-induced apoptosis by regulating energy metabolism. Our results revealed that RSV protects neutrophils from PA-induced apoptosis by shifting glucose metabolism to lipid metabolism. This study tenders to a meaningful understanding of the effects of RSV on neutrophils function in periparturient cows suffering from negative energy balance (NEB)"
Keywords:		"Animals Cattle Female Energy Metabolism Fatty Acids, Nonesterified *Glucose/metabolism *Lipid Metabolism/drug effects *Neutrophils/metabolism *Palmitic Acid/pharmacology *Resveratrol/pharmacology *Apoptosis/drug effects Fatty acid oxidation Glycolysis Neu;"
Notes:		"MedlineLi, Yansong Zhang, Yuming Deng, Qinghua Mao, Jingdong Jia, Zhenwei Tang, Mingyu Zhang, Yue Zhao, Junkang Chen, Jiaojiao Wang, Yiru Feng, Ziying Wang, Xinbo Du, Liyin eng Research Support, Non-U.S. Gov't England 2023/07/17 J Steroid Biochem Mol Biol. 2023 Oct; 233:106363. doi: 10.1016/j.jsbmb.2023.106363. Epub 2023 Jul 15"