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Microbiol Mol Biol Rev

Title:		Signal transduction cascades regulating fungal development and virulence
Author(s):		Lengeler KB; Davidson RC; D'Souza C; Harashima T; Shen WC; Wang P; Pan X; Waugh M; Heitman J;
Address:		"Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA"
Journal Title:		Microbiol Mol Biol Rev
Year:		2000
Volume:		64
Issue:		4
Page Number:		746 - 785
DOI:		10.1128/MMBR.64.4.746-785.2000
ISSN/ISBN:		1092-2172 (Print) 1098-5557 (Electronic) 1092-2172 (Linking)
Abstract:		"Cellular differentiation, mating, and filamentous growth are regulated in many fungi by environmental and nutritional signals. For example, in response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae undergo a dimorphic transition to filamentous growth referred to as pseudohyphal differentiation. Yeast filamentous growth is regulated, in part, by two conserved signal transduction cascades: a mitogen-activated protein kinase cascade and a G-protein regulated cyclic AMP signaling pathway. Related signaling cascades play an analogous role in regulating mating and virulence in the plant fungal pathogen Ustilago maydis and the human fungal pathogens Cryptococcus neoformans and Candida albicans. We review here studies on the signaling cascades that regulate development of these and other fungi. This analysis illustrates both how the model yeast S. cerevisiae can serve as a paradigm for signaling in other organisms and also how studies in other fungi provide insights into conserved signaling pathways that operate in many divergent organisms"
Keywords:		Calcineurin/metabolism Cyclic AMP/metabolism Cyclic AMP-Dependent Protein Kinases/metabolism Fungi/cytology/metabolism/*pathogenicity GTP-Binding Proteins/metabolism MAP Kinase Signaling System Pheromones Receptor Cross-Talk Transcription Factors/metaboli;
Notes:		"MedlineLengeler, K B Davidson, R C D'souza, C Harashima, T Shen, W C Wang, P Pan, X Waugh, M Heitman, J eng R37 AI039115/AI/NIAID NIH HHS/ R01 AI042159/AI/NIAID NIH HHS/ R01 AI42159/AI/NIAID NIH HHS/ R01 AI039115/AI/NIAID NIH HHS/ R01 AI41937/AI/NIAID NIH HHS/ R01 AI39115/AI/NIAID NIH HHS/ P01 AI044975/AI/NIAID NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review 2000/12/06 Microbiol Mol Biol Rev. 2000 Dec; 64(4):746-85. doi: 10.1128/MMBR.64.4.746-785.2000"