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J Am Chem Soc

Title:		'Volatilizable' supports for high-throughput organic synthesis
Author(s):		Houghten RA; Yu Y;
Address:		"Torrey Pines Institute for Molecular Studies and Mixture Sciences Inc., 3550 General Atomics Court, San Diego, California 92121, USA. houghten@tpims.org"
Journal Title:		J Am Chem Soc
Year:		2005
Volume:		127
Issue:		24
Page Number:		8582 - 8583
DOI:		10.1021/ja0402396
ISSN/ISBN:		0002-7863 (Print) 0002-7863 (Linking)
Abstract:		"The concepts and use of 'volatilizable' solid supports are presented. Such supports, which are completely removed by volatilization following decomposition, improve the efficiency of the solid-phase synthesis of both individual and mixtures of low-molecular weight acyclic and heterocyclic compounds as well as peptides, peptidomimetics, and protected peptide fragments. The 'volatilizable' silica-based solid supports and linkers used to illustrate this concept were found to be completely removed by their decomposition and ultimate 'volatilization' during the final cleavage step of synthetic process to yield solely the desired synthetic product(s) in the final reaction vessel"
Keywords:		"Chemistry, Organic/methods Cross-Linking Reagents/chemistry Oligopeptides/*chemical synthesis Silica Gel Silicon Dioxide/*chemistry Volatilization;"
Notes:		"MedlineHoughten, Richard A Yu, Yongping eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2005/06/16 J Am Chem Soc. 2005 Jun 22; 127(24):8582-3. doi: 10.1021/ja0402396"