« Previous AbstractVPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment    Next AbstractSexual selection on Drosophila serrata male pheromones does not vary with female age or mating status »

Med Mycol

Title:		Profiling of volatile organic compounds produced by clinical Aspergillus isolates using gas chromatography-mass spectrometry
Author(s):		Gerritsen MG; Brinkman P; Escobar N; Bos LD; de Heer K; Meijer M; Janssen HG; de Cock H; Wosten HAB; Visser CE; van Oers MHJ; Sterk PJ;
Address:		"Department of Hematology, Academic Medical Center - University of Amsterdam, Amsterdam, the Netherlands. Department of Respiratory Medicine, Academic Medical Center - University of Amsterdam, Amsterdam, the Netherlands. Microbiology, Department of Biology, Utrecht University, Utrecht, the Netherlands. Department of Intensive Care, Academic Medical Center - University of Amsterdam, Amsterdam, the Netherlands. Applied and Industrial Mycology, Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands. Analytical Chemistry Group, University of Amsterdam, Amsterdam, the Netherlands. Department of Medical Microbiology, Academic Medical Center - University of Amsterdam, Amsterdam, the Netherlands"
Journal Title:		Med Mycol
Year:		2018
Volume:		56
Issue:		2
Page Number:		253 - 256
DOI:		10.1093/mmy/myx035
ISSN/ISBN:		1460-2709 (Electronic) 1369-3786 (Linking)
Abstract:		"Volatile organic compounds (VOCs) in exhaled breath may identify the presence of invasive pulmonary aspergillosis. We aimed to detect VOC profiles emitted by in vitro cultured, clinical Aspergillus isolates using gas chromatography-mass spectrometry (GC-MS). Three clinical Aspergillus isolates and a reference strain were cultured while conidiation was prevented. Headspace samples were analyzed using a standardized method. Breath samples of patients from which the cultures were obtained were checked for the presence of the VOCs found in vitro. Each Aspergillus isolate produced a distinct VOC profile. These profiles could not be confirmed in exhaled breath in vivo"
Keywords:		Aspergillus/classification/isolation & purification/*metabolism *Breath Tests *Gas Chromatography-Mass Spectrometry Humans Invasive Pulmonary Aspergillosis/*diagnosis/physiopathology Volatile Organic Compounds/*chemistry Aspergillus exhaled breath analysi;
Notes:		"MedlineGerritsen, M G Brinkman, P Escobar, N Bos, L D de Heer, K Meijer, M Janssen, H-G de Cock, H Wosten, H A B Visser, C E van Oers, M H J Sterk, P J eng Clinical Trial England 2017/05/20 Med Mycol. 2018 Feb 1; 56(2):253-256. doi: 10.1093/mmy/myx035"