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Eur J Neurosci

Title:		A common gene exclusion mechanism used by two chemosensory systems
Author(s):		Capello L; Roppolo D; Jungo VP; Feinstein P; Rodriguez I;
Address:		"Department of Zoology and Animal Biology, and NCCR Frontiers in Genetics, University of Geneva, Geneva, Switzerland"
Journal Title:		Eur J Neurosci
Year:		2009
Volume:		20090206
Issue:		4
Page Number:		671 - 678
DOI:		10.1111/j.1460-9568.2009.06630.x
ISSN/ISBN:		1460-9568 (Electronic) 0953-816X (Print) 0953-816X (Linking)
Abstract:		"Sensory coding strategies within vertebrates involve the expression of a limited number of receptor types per sensory cell. In mice, each vomeronasal sensory neuron transcribes monoallelically a single V1R pheromone receptor gene, chosen from a large V1R repertoire. The nature of the signals leading to this strict receptor expression is unknown, but is apparently based on a negative feedback mechanism initiated by the transcription of the first randomly chosen functional V1R gene. We show, in vivo, that the genetic replacement of the V1rb2 pheromone receptor coding sequence by an unrelated one from the odorant receptor gene M71 maintains gene exclusion. The expression of this exogenous odorant receptor in vomeronasal neurons does not trigger the transcription of odorant receptor-associated signalling molecules. These results strongly suggest that despite the different odorant and vomeronasal receptor expression sites, function and transduction cascades, a common mechanism is used by these chemoreceptors to regulate their transcription"
Keywords:		"Amino Acid Sequence Animals Female *Gene Expression Regulation Gene Knock-In Techniques Immunohistochemistry In Situ Hybridization Male Mice Mice, Transgenic Microscopy, Confocal Molecular Sequence Data Olfactory Bulb/metabolism Olfactory Receptor Neurons;"
Notes:		"MedlineCapello, Luca Roppolo, Daniele Jungo, Veronique Pauli Feinstein, Paul Rodriguez, Ivan eng R03 DC007340/DC/NIDCD NIH HHS/ R03 DC007340-04/DC/NIDCD NIH HHS/ SC1 GM088114/GM/NIGMS NIH HHS/ NCRRRCMI03037/PHS HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't France 2009/02/10 Eur J Neurosci. 2009 Feb; 29(4):671-8. doi: 10.1111/j.1460-9568.2009.06630.x. Epub 2009 Feb 6"