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Pharmacogn Mag
| Title: | Secondary Metabolites from Leaves of Manilkara subsericea (Mart.) Dubard |
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| Author(s): | de Almeida FB; Fernandes CP; Romao W; Vanini G; Costa HB; Franca HS; Santos MG; Carvalho JC; Falcao DQ; Rocha L; |
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| Address: | "Laboratorio de Nanobiotecnologia Fitofarmaceutica, Colegiado de Farmacia, Universidade Federal do Amapa, Campus Universitario Marco Zero do Equador, Rodovia Juscelino Kubitschek de Oliveira, KM, 02 Bairro Zerao, CEP: 68902-280, Macapa, AP, Brazil. Laboratorio de Nanobiotecnologia Fitofarmaceutica, Colegiado de Farmacia, Universidade Federal do Amapa, Campus Universitario Marco Zero do Equador, Rodovia Juscelino Kubitschek de Oliveira, KM, 02 Bairro Zerao, CEP: 68902-280, Macapa, AP, Brazil; Programa de Pos, Graduacao em Biotecnologia Vegetal, Centro de Ciencias da Saude, Bloco K, 2 degrees Andar, Sala 032, Universidade Federal do Rio de Janeiro, UFRJ, Av. Brigadeiro Trompowski s/n, CEP: 21941-590, Ilha do Fundao, RJ, Brazil. Laboratorio de Petroleomica e Forense, Departamento de Quimica, Universidade Federal do Espirito Santo, CEP: 29075-910, Vitoria, ES, Brazil; Instituto Federal de Educacao, Ciencia e Tecnologia do Espirito Santo, CEP: 29106-010, Vila Velha, ES, Brazil. Laboratorio de Petroleomica e Forense, Departamento de Quimica, Universidade Federal do Espirito Santo, CEP: 29075-910, Vitoria, ES, Brazil. Instituto Federal de Educacao, Ciencia e Tecnologia do Espirito Santo, CEP: 29106-010, Vila Velha, ES, Brazil. Faculdade de Formacao de Professores, UERJ, Rua: Dr. Francisco Portela, 1470, Patronato, CEP: 24435-005, Sao Goncalo, Rio de Janeiro, Brazil. Laboratorio de Pesquisa em Farmacos, Colegiado de Farmacia, Universidade Federal do Amapa, Campus Universitario Marco Zero do Equador, Rod. Juscelino Kubitschek de Oliveira, KM-02, Bairro Zerao, CEP 68902-280 Macapa, AP, Brazil. Laboratorio de Tecnologia Farmaceutica, Departamento e Tecnologia Farmaceutica, Faculdade de Farmacia, Universidade Federal Fluminense, UFF Rua: Mario Viana, 523, CEP: 24241-000, Santa Rosa, Niteroi, Brazil. Programa de Pos, Graduacao em Biotecnologia Vegetal, Centro de Ciencias da Saude, Bloco K, 2 degrees Andar, Sala 032, Universidade Federal do Rio de Janeiro, UFRJ, Av. Brigadeiro Trompowski s/n, CEP: 21941-590, Ilha do Fundao, RJ, Brazil; Laboratorio de Tecnologia de Produtos Naturais, LTPN, Departamento e Tecnologia Farmaceutica, Faculdade de Farmacia, Universidade Federal Fluminense, UFF Rua: Mario Viana, 523, CEP: 24241-000, Santa Rosa, Niteroi, RJ, Brazil" |
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| Journal Title: | Pharmacogn Mag |
| Year: | 2015 |
| Volume: | 11 |
| Issue: | Suppl 4 |
| Page Number: | S533 - S537 |
| DOI: | 10.4103/0973-1296.172957 |
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| ISSN/ISBN: | 0973-1296 (Print) 0976-4062 (Electronic) 0973-1296 (Linking) |
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| Abstract: | "BACKGROUND: Manilkara subsericea (Sapotaceae) is a species widely spread in the sandbanks of Restinga de Jurubatiba National Park (Rio de Janeiro, Brazil). It is commonly known as 'macaranduba', 'macarandubinha' and 'guracica', being used in this locality as food, and timber. However, M. subsericea remains almost unexplored regarding its chemical constituents, including secondary metabolites from the leaves. OBJECTIVE: Identify the chemical constituents from the leaves of M. subsericea. MATERIALS AND METHODS: Leaves were macerated with ethanol (96% v/v), and dried crude ethanolic extract was sequentially washed with the organic solvents in order to obtain an ethyl acetate fraction. Substances from this fraction were identified by different techniques, such as negative-ion electrospray ionization Fourier and (1)H and (13)C nuclear magnetic resonance (NMR). Fresh leaves from M. subsericea were also submitted to hydrodistillation in order to obtain volatile substances, which were identified by gas chromatograph coupled to mass spectrometer. RESULTS: NMR(1)H and (13)C spectra allowed for the identification of the compounds myricetin, quercetin, and kaempferol from the ethyl acetate fraction. The negative-ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry mass spectrum also revealed the presence in this fraction of a polyhydroxytriterpene acid (pomolic acid), and some flavonoids, such as quercitrin, and myricitrin. In all 34 volatile compounds were identified by gas chromatography-mass spectrometry, including monoterpenes, sesquiterpenes, and long chain hydrocarbons. CONCLUSION: This study describes the first reports concerning the phytochemical information about leaves from M. subsericea. SUMMARY: Manilkara subsericea fruits proved to be a rich source of triterpenes. However, no phytochemical studies were carried out with leaves. Thus, we described identification of volatile substances from its essential oils, in addition to non-reported triterpene and flavonoids from this species" |
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| Keywords: | Essential oil Manilkara subsericea flavonoids mass spectrometry pomolic acid sapotaceae; |
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| Notes: | "PubMed-not-MEDLINEde Almeida, Fernanda Borges Fernandes, Caio Pinho Romao, Wanderson Vanini, Gabriela Costa, Helber Barcelos Franca, Hildegardo Seibert Santos, Marcelo Guerra Carvalho, Jose Carlos Tavares Falcao, Deborah Quintanilha Rocha, Leandro eng 2016/03/26 Pharmacogn Mag. 2015 Oct; 11(Suppl 4):S533-7. doi: 10.4103/0973-1296.172957" |
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