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« Previous AbstractStoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway    Next Abstract"Release of chemicals by prostaglandin-treated female fathead minnows, Pimephales promelas, that stimulate male courtship" »

Cell


Title:Pheromone-induced phosphorylation of a G protein beta subunit in S. cerevisiae is associated with an adaptive response to mating pheromone
Author(s):Cole GM; Reed SI;
Address:"Molecular Biology Department, Research Institute of Scripps Clinic, La Jolla, California 92037"
Journal Title:Cell
Year:1991
Volume:64
Issue:4
Page Number:703 - 716
DOI: 10.1016/0092-8674(91)90500-x
ISSN/ISBN:0092-8674 (Print) 0092-8674 (Linking)
Abstract:"The mating pheromone response in S. cerevisiae is activated by a G protein-mediated signaling pathway in which G beta gamma is the active transducer of the signal. When exogenous pheromone is added to vegetatively growing cells, G beta is rapidly phosphorylated at several sites; phosphorylation does not require de novo protein synthesis. A mutation in G beta was constructed that eliminates signal-induced phosphorylation. This mutation leads to enhanced sensitivity to and impaired ability to recover from pheromone, but does not affect the ability of G beta gamma to transmit the mating signal. These phenotypes suggest that G protein phosphorylation mediates an adaptive response to pheromone-induced signaling. G beta phosphorylation does not require either the pheromone receptor C-terminus or the product of the SST2 gene, both of which mediate separate adaptive responses to pheromone. However, G beta phosphorylation is greatly facilitated by the presence of the G alpha subunit, which has also been shown to participate in an adaptation to pheromone"
Keywords:"Amino Acid Sequence Amino Acids/analysis Chromosome Deletion Crosses, Genetic *GTP-Binding Protein beta Subunits GTP-Binding Proteins/genetics/*metabolism Genes, Fungal Genotype *Heterotrimeric GTP-Binding Proteins Macromolecular Substances Mating Factor;"
Notes:"MedlineCole, G M Reed, S I eng GM 13116/GM/NIGMS NIH HHS/ GM49429/GM/NIGMS NIH HHS/ Comparative Study Research Support, U.S. Gov't, P.H.S. 1991/02/22 Cell. 1991 Feb 22; 64(4):703-16. doi: 10.1016/0092-8674(91)90500-x"

 
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