| Title: | Patterns of volatile organic compounds in excrements of preterm neonates |
| Author(s): | Bous M; Tutdibi E; Nourkami-Tutdibi N; Kaiser E; Stutz R; Meyer S; Baumbach JI; Zemlin M; Goedicke-Fritz S; |
| Address: | "Department of General Pediatrics and Neonatology, Saarland University Medical School, Homburg, Germany. Department Bio- and Chemical Engineering, Technical University Dortmund, Dortmund, Germany" |
| ISSN/ISBN: | 1365-2362 (Electronic) 0014-2972 (Linking) |
| Abstract: | "BACKGROUND: As neonates are susceptible for many diseases, establishing noninvasive diagnostic methods is desirable. We hypothesized that volatile organic compounds (VOCs) could be successfully measured in diaper samples. METHODS: We performed a feasibility study to investigate whether ambient air-independent headspace measurements of the VOC profiles of diapers from premature infants can be conducted using ion mobility spectrometer coupled with multi-capillary columns (B & S Analytik GmbH). RESULTS: We analysed 39 diapers filled with stool (n = 10) or urine (n = 20) respectively, using empty diapers as a control (n = 9). A total of 158 different VOCs were identified, and we classified the content of the diapers (urine or stool) according to their VOC profiles with a significance level of p < 0.05. CONCLUSIONS: We have developed a novel method to study headspace VOC profiles of biosamples using ion mobility spectrometry coupled with multi-capillary columns. Using this method, we have characterized the VOC profiles of stool and urine of preterm neonates. Future studies are warranted to characterize specific VOC profiles in infections and other diseases of the preterm neonate, thus establishing quick and noninvasive diagnostics in the routine care of the highly vulnerable preterm and term neonates" |
| Keywords: | "Infant, Newborn Humans *Volatile Organic Compounds/urine Feces/chemistry Ims Voc ion mobility spectrometry neonatology noninvasive diagnostics volatile organic compounds;" |
| Notes: | "MedlineBous, Michelle Tutdibi, Erol Nourkami-Tutdibi, Nasenien Kaiser, Elisabeth Stutz, Regine Meyer, Sascha Baumbach, Jorg Ingo Zemlin, Michael Goedicke-Fritz, Sybelle eng 01GL1746D/Bundesministerium fur Bildung und Forschung/ Centre of Digital Neurotechnologies Saar/ Else-Kroner-Fresenius Stiftung/ Saarland University Medical School/ Staatskanzlei Saarbrucken/ England 2022/09/06 Eur J Clin Invest. 2023 Jan; 53(1):e13868. doi: 10.1111/eci.13868. Epub 2022 Sep 15" |
