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Biosens Bioelectron

Title:		'Seeing' invisible volatile organic compound (VOC) marker of urinary bladder cancer: A development from bench to bedside prototype spectroscopic device
Author(s):		Bhattacharyya N; Mukherjee D; Singh S; Ghosh R; Karmakar S; Mallick A; Chattopadhyay A; Mondal P; Mondal T; Bhattacharyya D; Mallick AK; Nabi G; Pal SK;
Address:		"Department of Radio Physics and Electronics, University of Calcutta, 92, Acharya Prafulla Chandra Rd, Machuabazar, Kolkata, 700009, India; Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata, 700106, India. Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata, 700106, India. Department of Urology, Nil Ratan Sircar Medical College & Hospital, 138, AJC Bose Road, Sealdah, Raja Bazar, Kolkata, 700014, India. Department of Radiation Oncology, K.G.M.U Lucknow, Shah Mina Rd, Chowk, Lucknow, Uttar Pradesh, 226003, India. Department of Basic Science and Humanities, Techno International New Town, Block - DG 1/1, Action Area 1, New Town, Rajarhat, Kolkata, 700156, India. Department of Radio Physics and Electronics, University of Calcutta, 92, Acharya Prafulla Chandra Rd, Machuabazar, Kolkata, 700009, India. Department of Gynecology & Obstetrics, Nil Ratan Sircar Medical College & Hospital, 138, AJC Bose Road, Sealdah, Raja Bazar, Kolkata, 700014, India. Department of Paediatrics, Nil Ratan Sircar Medical College and Hospital, Kolkata, 700014, India. Division of Imaging Science and Technology, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK. Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata, 700106, India. Electronic address: skpal@bose.res.in"
Journal Title:		Biosens Bioelectron
Year:		2022
Volume:		20220929
Issue:
Page Number:		114764 -
DOI:		10.1016/j.bios.2022.114764
ISSN/ISBN:		1873-4235 (Electronic) 0956-5663 (Linking)
Abstract:		"Urinary bladder cancer (UBC) is one of the most common cancers and has notoriously high risk of recurrence and mortality across the globe. Current clinical initial diagnostic approaches are either invasive or lacks sensitivity. In this study, an attempt has been made to invent a cost-effective, novel, portable diagnostic device based on the environmental sensitive fluorophores namely Nile Red (NR), Eosin Y (EY) and Rose Bengal (RB). They act as sensing agents for detecting volatile organic compounds (VOC) exclusively present in the urine sample of UBC patients and differentiate the UBC samples from the healthy control group. Upon exposure with a particular group of VOCs, a significant amount of increment in fluorescence intensities of NR, EY and RB were detected and recorded in our indigenously developed 'NABIL' device. To check the performance of NABIL, the data collected from the device was compared with the conventional techniques by arranging a clinical trial with 21 healthy controls and 52 UBC patients. With the assistance of our analysis technique based on LabVIEW platform, very high sensitivity and accuracy from healthy controls have been achieved. For UBC patients, it shows impressive diagnostic results. In addition, depending on the sample processing mechanism, NABIL device can also reveal the grade of UBC and prognosis under treatment. Overall, this study contributes a novel, non-invasive, easy-to-use, inexpensive, real-time, accurate method for selectively UBC diagnosis, which can be useful for personalized care/diagnosis and postoperative surveillance, resulting in saving more lives"
Keywords:		"Humans Biomarkers Biomarkers, Tumor/urine *Biosensing Techniques Eosine Yellowish-(YS) Rose Bengal *Urinary Bladder Neoplasms/diagnosis/urine *Volatile Organic Compounds Non-invasive diagnosis Spectroscopic detection Urinary bladder cancer Volatile organi;"
Notes:		"MedlineBhattacharyya, Neha Mukherjee, Dipanjan Singh, Soumendra Ghosh, Ria Karmakar, Saurav Mallick, Ankita Chattopadhyay, Arpita Mondal, Pulak Mondal, Tapan Bhattacharyya, Debasis Mallick, Asim Kumar Nabi, Ghulam Pal, Samir Kumar eng Clinical Trial England 2022/10/08 Biosens Bioelectron. 2022 Dec 15; 218:114764. doi: 10.1016/j.bios.2022.114764. Epub 2022 Sep 29"