| Title: | Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications |
| Author(s): | Arslanov DD; Castro MP; Creemers NA; Neerincx AH; Spunei M; Mandon J; Cristescu SM; Merkus P; Harren FJ; |
| Address: | "Radboud University Nijmegen, Life Science Trace Gas Research Group, Molecular and Laser Physics, Institute for Molecules and Materials, Nijmegen, The Netherlands" |
| DOI: | 10.1117/1.JBO.18.10.107002 |
| ISSN/ISBN: | 1560-2281 (Electronic) 1083-3668 (Linking) |
| Abstract: | "A versatile, continuous wave, optical parametric oscillator is used in combination with photoacoustic spectroscopy for long-term trace gas experiments of volatile compounds emitted by biological samples. The optical parametric oscillator-based spectrometer (wavelength near 3 mum, 8-MHz linewidth, output power approximately 1 W) is successfully tested for the detection of hydrogen cyanide (HCN) emission from clover leaves, and Pseudomonas bacteria; in addition, the presence of HCN in exhaled human breath is measured. For specific experiments, the spectrometer is operated continuously up to 10 days and has a detection limit of 0.4 parts-per-billion volume of HCN in air over 10 s, using the P8 rotational line in the nu(3) vibrational band of HCN at 3287.25 cm(-)(1). This results in an overall sensitivity of the system of 2.5 x 10(-)(9) cm-1 Hz(-)(1)/(2)" |
| Keywords: | Breath Tests/*methods Gases/analysis Humans Hydrogen Cyanide/*analysis Limit of Detection Photoacoustic Techniques/*methods Plant Leaves/chemistry Pseudomonas/metabolism Trifolium/chemistry Volatile Organic Compounds/analysis; |
| Notes: | "MedlineArslanov, Denis D Castro, Maria P P Creemers, Noortje A Neerincx, Anne H Spunei, Marius Mandon, Julien Cristescu, Simona M Merkus, Peter Harren, Frans J M eng Research Support, Non-U.S. Gov't 2013/10/04 J Biomed Opt. 2013 Oct; 18(10):107002. doi: 10.1117/1.JBO.18.10.107002" |
