| Title: | A Maternal Low-Fiber Diet Predisposes Offspring to Improved Metabolic Phenotypes in Adulthood in an Herbivorous Rodent |
| Author(s): | Zhang XY; Lou MF; Shen W; Fu RS; Wang DH; |
| ISSN/ISBN: | 1537-5293 (Electronic) 1522-2152 (Linking) |
| Abstract: | "The maternal or paternal dietary composition can have important effects on various aspects of their offspring's physiology. Studies from animal models and humans showed that a maternal high-fiber diet protected offspring against fat accumulation. However, little is known about how a maternal low-fiber diet modifies the metabolism of offspring in herbivorous rodents. We hypothesized that a maternal low-fiber diet would confer long-lasting beneficial effects on offspring metabolic phenotypes in herbivorous Brandt's vole (Lasiopodomys brandtii). Female voles were fed either a control (12.4% fiber) or a low-fiber (3.5% fiber) diet throughout pregnancy and lactation, and all offspring were fed the control diet after weaning till 14 wk old. Offspring were sampled from each litter at 18 d and 14 wk of age. Another subset of adult offspring at 15 wk of age was fed a high-fat diet for 8 wk. We found that there was no difference in litter size, litter mass, or pup mass before weaning between the two maternal diet groups. Offspring from the maternal low-fiber diet increased energy intake, body mass, and lean mass; suppressed fat accumulation; and improved glucose tolerance compared with those from the control diet. Moreover, the maternal low-fiber diet alleviated high-fat diet-induced obesity in the adult offspring. Serum leptin concentration and uncoupling protein 1 content in brown adipose tissue of offspring were not affected by a maternal low-fiber diet. We demonstrate that herbivorous females fed a low-fiber diet during pregnancy and lactation may predispose their offspring to accelerated growth of lean tissue, which may increase the opportunity for survival and reproduction in offspring" |
| Keywords: | Aging Animal Feed/*analysis Animal Nutritional Physiological Phenomena Animals Arvicolinae/*physiology Body Composition Body Weight Diet/*veterinary Dietary Fiber/*administration & dosage Energy Intake Female Pregnancy Prenatal Exposure Delayed Effects *P; |
| Notes: | "MedlineZhang, Xue-Ying Lou, Mei-Fang Shen, Wei Fu, Rong-Shu Wang, De-Hua eng Research Support, Non-U.S. Gov't 2017/01/05 Physiol Biochem Zool. 2017 Jan/Feb; 90(1):75-84. doi: 10.1086/688978. Epub 2016 Oct 17" |
