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Front Microbiol

Title:		Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts
Author(s):		Zhang X; Miao Q; Xu X; Ji B; Qu L; Wei Y;
Address:		"Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China. Laboratory of Synthetic Biology, Zhengzhou University, Zhengzhou, China. Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. College of Chemistry, Zhengzhou University, Zhengzhou, China"
Journal Title:		Front Microbiol
Year:		2021
Volume:		20211111
Issue:
Page Number:		759975 -
DOI:		10.3389/fmicb.2021.759975
ISSN/ISBN:		1664-302X (Print) 1664-302X (Electronic) 1664-302X (Linking)
Abstract:		"The use of traditional chemical insecticides for pest control often leads to environmental pollution and a decrease in biodiversity. Recently, insect sex pheromones were applied for sustainable biocontrol of pests in fields, due to their limited adverse impacts on biodiversity and food safety compared to that of other conventional insecticides. However, the structures of insect pheromones are complex, and their chemical synthesis is not commercially feasible. As yeasts have been widely used for fatty acid-derived pheromone production in the past few years, using engineered yeasts may be promising and sustainable for the low-cost production of fatty acid-derived pheromones. The primary fatty acids produced by Saccharomyces cerevisiae and other yeasts are C16 and C18, and it is also possible to rewire/reprogram the metabolic flux for other fatty acids or fatty acid derivatives. This review summarizes the fatty acid biosynthetic pathway in S. cerevisiae and recent progress in yeast engineering in terms of metabolic engineering and synthetic biology strategies to produce insect pheromones. In the future, insect pheromones produced by yeasts might provide an eco-friendly pest control method in agricultural fields"
Keywords:		Saccharomyces cerevisiae fatty acids insect sex pheromone metabolic engineering synthetic biology;
Notes:		"PubMed-not-MEDLINEZhang, Xiaoling Miao, Qin Xu, Xia Ji, Boyang Qu, Lingbo Wei, Yongjun eng Review Switzerland 2021/12/04 Front Microbiol. 2021 Nov 11; 12:759975. doi: 10.3389/fmicb.2021.759975. eCollection 2021"