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RSC Adv

Title:		N-Carbamylglutamate and l-arginine supplementation improve hepatic antioxidant status in intrauterine growth-retarded suckling lambs
Author(s):		Zhang H; Jin Y; Wang M; Loor JJ; Wang H;
Address:		"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University Yangzhou 225009 P. R. China hrwang@yzu.edu.cn. Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University Yangzhou 225009 P. R. China. Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois Urbana IL 61801 USA"
Journal Title:		RSC Adv
Year:		2020
Volume:		20200318
Issue:		19
Page Number:		11173 - 11181
DOI:		10.1039/c9ra09316h
ISSN/ISBN:		2046-2069 (Electronic) 2046-2069 (Linking)
Abstract:		"The influence of dietary supplementation of l-arginine (Arg) or N-carbamylglutamate (NCG) on the hepatic antioxidant status in intrauterine-growth-retarded (IUGR) suckling lambs remains unclear. The current work aimed to investigate the regulatory mechanisms whereby dietary Arg or NCG alter hepatic antioxidant status in suckling lambs suffering from IUGR. Forty-eight newborn Hu lambs of normal birth weight (CON) and IUGR were allocated randomly into four groups of 12 animals each: CON (4.25 +/- 0.14 kg), IUGR (3.01 +/- 0.12 kg), IUGR + 1% Arg (2.99 +/- 0.13 kg), or IUGR + 0.1% NCG (3.03 +/- 0.11 kg). All lambs were raised for a period of 21 days from 7 to 28 days after birth. Compared with the IUGR suckling animals, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and reduced glutathione (GSH) content were greater (P < 0.05), and protein carbonyl and malondialdehyde (MDA) levels were reduced (P < 0.05) in the livers of both IUGR + 1% Arg and 0.1% NCG suckling animals. Relative to IUGR suckling lambs, supplementing with Arg or NCG markedly reduced (P < 0.05) reactive oxygen species (ROS) levels, apoptosis, and necrosis in liver. Relative to IUGR suckling lambs, protein and mRNA expression of GSH-Px1, SOD2, catalase (CAT), heme oxygenase-1 (HO-1), inducible nitric oxide (NO) synthase (iNOS), and epithelial NO synthase (eNOS) increased in IUGR animals receiving Arg or NCG (P < 0.05). Both Arg and NCG can protect neonates from IUGR-induced hepatic oxidative damage through promoting the expression of antioxidative enzymes (including SOD, CAT, and GSH-Px), phase II metabolizing enzymes, and activation of the NO pathway"
Keywords:
Notes:		"PubMed-not-MEDLINEZhang, Hao Jin, Yaqian Wang, Mengzhi Loor, Juan J Wang, Hongrong eng England 2020/03/18 RSC Adv. 2020 Mar 18; 10(19):11173-11181. doi: 10.1039/c9ra09316h. eCollection 2020 Mar 16"