| Title: | Conditional genetic labeling of mitral cells of the mouse accessory olfactory bulb to visualize the organization of their apical dendritic tufts |
| Address: | "Molecular Neurogenetics Unit, HMRO, Kyoto University Graduate School of Medicine, Yoshida-Konoe, Sakyo, Kyoto 606-8501, Japan" |
| DOI: | 10.1016/j.mcn.2007.12.016 |
| ISSN/ISBN: | 1095-9327 (Electronic) 1044-7431 (Linking) |
| Abstract: | "Chemical information captured through the vomeronasal sensory neurons is transmitted to mitral cells in the accessory olfactory bulb (AOB). Morphological characterization of AOB mitral cells is crucial to reveal the mechanisms underlying pheromone and other chemical information processing. Here, we developed a conditional genetic approach to visualize single AOB mitral cells in mice and analyzed the distribution of their apical dendritic tufts and cell bodies. We found that there is a subpopulation of superficial AOB mitral cells with small cell bodies and simple dendritic arborization. We also showed that segregation of the anterior and posterior AOB appears incomplete at the level of the mitral cell positions. Furthermore, we demonstrated that significant population of the anterior AOB mitral cells has multiple apical dendritic tufts organized in a quite small range along the dorsal-ventral axis. These findings have important implications in how various chemical signals may be processed in the AOB" |
| Keywords: | "Animals Brain Mapping/methods Dendrites/chemistry/*genetics/*ultrastructure Mice Mice, Inbred C57BL Mice, Transgenic Olfactory Bulb/chemistry/*cytology/*physiology;" |
| Notes: | "MedlineYonekura, Junichiro Yokoi, Mineto eng Comparative Study Research Support, Non-U.S. Gov't 2008/01/19 Mol Cell Neurosci. 2008 Apr; 37(4):708-18. doi: 10.1016/j.mcn.2007.12.016. Epub 2007 Dec 15" |
