| Title: | Influence of synthetic peptide inducers on antibacterial activity of enterococci |
| Author(s): | Yermolenko E; Chernysh A; Kolobov A; Suvorov A; |
| Address: | "Department of Molecular Microbiology, Institute of Experimental Medicine, St. Petersburg, Russia" |
| ISSN/ISBN: | 1876-2891 (Electronic) 1876-2883 (Linking) |
| Abstract: | "Antibacterial activity of probiotic enterococci is often related to the production of bacteriocins. There is a variety of Enterococcus faecium strains which synthesise one or several enterocins including A, B, P, 96, L50AB and others. In this work we have analysed the probiotic strain E. faecium L3 whose genome contained the genes encoding enterocins capital A, Cyrillic, capital VE, Cyrillic and a three-component regulatory system. All these genes were found to be expressed in enterococcal strain L3. Antimicrobial activity of the strain tested on the strains of Listeria monocytogenes and Streptococcus agalactiae was pheromone dependent. Chemically synthesised cyclic peptides (analogues and shorter derivates of EntF) with different molecular structures were able to increase the antagonistic activity of the strain E. faecium L3 in contrast to the strain E. faecium SF68, which does nsmall o, Cyrillict have genes encoding enterocins capital A, Cyrillic and capital VE, Cyrillic" |
| Keywords: | "Anti-Bacterial Agents/*pharmacology Bacteriocins/biosynthesis Enterococcus faecalis/*drug effects/genetics/metabolism Gene Expression Regulation, Bacterial Genes, Bacterial Listeria monocytogenes/physiology Peptides/chemistry/*pharmacology Probiotics/*pha;" |
| Notes: | "MedlineYermolenko, E Chernysh, A Kolobov, A Suvorov, A eng Netherlands 2011/08/16 Benef Microbes. 2011 Mar; 2(1):9-13. doi: 10.3920/BM2010.0006" |
