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Mater Sci Eng C Mater Biol Appl

Title:		Fluorescent probe based on heteroatom containing styrylcyanine: pH-sensitive properties and bioimaging in vivo
Author(s):		Yang X; Gao Y; Huang Z; Chen X; Ke Z; Zhao P; Yan Y; Liu R; Qu J;
Address:		"School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China. School of Basic Medical Science, Southern Medical University, Guangzhou 510515, PR China. Department of Organic Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Department of Organic Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address: ruiyliu@smu.edu.cn. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China. Electronic address: cejqqu@scut.edu.cn"
Journal Title:		Mater Sci Eng C Mater Biol Appl
Year:		2015
Volume:		20150324
Issue:
Page Number:		97 - 102
DOI:		10.1016/j.msec.2015.03.042
ISSN/ISBN:		1873-0191 (Electronic) 0928-4931 (Linking)
Abstract:		"A novel fluorescent probe based on heteroatom containing styrylcyanine is synthesized. The fluorescence of probe is bright green in basic and neutral media but dark orange in strong acidic environments, which could be reversibly switched. Such behavior enables it to work as a fluorescent pH sensor in the solution state and a chemosensor for detecting acidic and basic volatile organic compounds. Analyses by NMR spectroscopy confirm that the protonation or deprotonation of pyridinyl moiety is responsible for the sensing process. In addition, the fluorescent microscopic images of probe in live cells and zebrafish are achieved successfully, suggesting that the probe has good cell membrane permeability and low cytotoxicity"
Keywords:		Diagnostic Imaging/*methods Fluorescent Dyes/*chemistry Hydrogen-Ion Concentration Bioimaging Chemosensor Fluorescent pH sensor Styrylcyanine;
Notes:		"MedlineYang, Xiaodong Gao, Ya Huang, Zhibing Chen, Xiaohui Ke, Zhiyong Zhao, Peiliang Yan, Yichen Liu, Ruiyuan Qu, Jinqing eng Research Support, Non-U.S. Gov't Netherlands 2015/05/09 Mater Sci Eng C Mater Biol Appl. 2015; 52:97-102. doi: 10.1016/j.msec.2015.03.042. Epub 2015 Mar 24"