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Int J Environ Res Public Health

Title:		Assessment of Exposure to VOCs among Pregnant Women in the National Children's Study
Author(s):		Boyle EB; Viet SM; Wright DJ; Merrill LS; Alwis KU; Blount BC; Mortensen ME; Moye J; Dellarco M;
Address:		"Health Studies, Westat, 1600 Research Blvd, Rockville, MD 20850, USA. eboyle@nas.edu. Health Studies, Westat, 1600 Research Blvd, Rockville, MD 20850, USA. SusanViet@westat.com. Health Studies, Westat, 1600 Research Blvd, Rockville, MD 20850, USA. DavidWright@Westat.com. Health Studies, Westat, 1600 Research Blvd, Rockville, MD 20850, USA. LoriMerrill@westat.com. Tobacco and Volatiles Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. eoe3@cdc.gov. Tobacco and Volatiles Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. bkb3@cdc.gov. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. zeo4@cdc.gov. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. moyej@exchange.nih.gov. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. dellarcom@mail.nih.gov"
Journal Title:		Int J Environ Res Public Health
Year:		2016
Volume:		20160329
Issue:		4
Page Number:		376 -
DOI:		10.3390/ijerph13040376
ISSN/ISBN:		1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking)
Abstract:		"Epidemiologic studies can measure exposure to volatile organic compounds (VOCs) using environmental samples, biomarkers, questionnaires, or observations. These different exposure assessment approaches each have advantages and disadvantages; thus, evaluating relationships is an important consideration. In the National Children's Vanguard Study from 2009 to 2010, participants completed questionnaires and data collectors observed VOC exposure sources and collected urine samples from 488 third trimester pregnant women at in-person study visits. From urine, we simultaneously quantified 28 VOC metabolites of exposure to acrolein, acrylamide, acrylonitrile, benzene, 1-bromopropane, 1,3-butadiene, carbon disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene, ethylene oxide, propylene oxide, styrene, tetrachloroethylene, toluene, trichloroethylene, vinyl chloride, and xylene exposures using ultra high performance liquid chromatography coupled with an electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS) method. Urinary thiocyanate was measured using an ion chromatography coupled with an electrospray ionization tandem mass spectrometry method (IC-ESI/MSMS). We modeled the relationship between urinary VOC metabolite concentrations and sources of VOC exposure. Sources of exposure were assessed by participant report via questionnaire (use of air fresheners, aerosols, paint or varnish, organic solvents, and passive/active smoking) and by observations by a trained data collector (presence of scented products in homes). We found several significant (p < 0.01) relationships between the urinary metabolites of VOCs and sources of VOC exposure. Smoking was positively associated with metabolites of the tobacco constituents acrolein, acrylamide, acrylonitrile, 1,3-butadiene, crotonaldehyde, cyanide, ethylene oxide, N,N-dimethylformamide, propylene oxide, styrene, and xylene. Study location was negatively associated with the toluene metabolite N-acetyl-S-(benzyl)-L-cysteine (BMA), and paint use was positively associated with the xylene metabolites 2-methylhippuric acid (2MHA) and 3-Methylhippuric acid & 4-methylhippuric acid (3MHA + 4MHA). A near-significant (p = 0.06) relationship was observed between acrylamide metabolites and observation of incense"
Keywords:		"Air Pollutants/*urine Biomarkers/urine Chromatography, High Pressure Liquid Environmental Monitoring Female Humans Pregnancy/*urine Smoking/urine Spectrometry, Mass, Electrospray Ionization Tobacco Smoke Pollution United States Volatile Organic Compounds/;"
Notes:		"MedlineBoyle, Elizabeth Barksdale Viet, Susan M Wright, David J Merrill, Lori S Alwis, K Udeni Blount, Benjamin C Mortensen, Mary E Moye, John Jr Dellarco, Michael eng HHSN275201200120U/PHS HHS/ Research Support, N.I.H., Extramural Switzerland 2016/04/05 Int J Environ Res Public Health. 2016 Mar 29; 13(4):376. doi: 10.3390/ijerph13040376"