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Head Neck

Title:		Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study
Author(s):		van de Goor R; Hardy JCA; van Hooren MRA; Kremer B; Kross KW;
Address:		"Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands. Department of Otorhinolaryngology, Head and Neck Surgery, Zuyderland Medical Center, Sittard-Geleen, The Netherlands"
Journal Title:		Head Neck
Year:		2019
Volume:		20190423
Issue:		9
Page Number:		2983 - 2990
DOI:		10.1002/hed.25787
ISSN/ISBN:		1097-0347 (Electronic) 1043-3074 (Print) 1043-3074 (Linking)
Abstract:		"BACKGROUND: The aim of this feasibility study was to assess the diagnostic performance of an electronic nose (e-nose) as a noninvasive diagnostic tool in detecting locoregional recurrent and/or second (or third) primary head and neck squamous cell carcinoma (HNSCC) after curative treatment. METHODS: Using an e-nose (Aeonose, The eNose Company, Zutphen, The Netherlands), breath samples were collected from patients after curative treatment of an HNSCC with a locoregional recurrence or second (or third) primary tumor (N = 20) and from patients without evidence of recurrent disease (N = 20). Analyses were performed utilizing artificial neural networking based on patterns of volatile organic compounds. RESULTS: A diagnostic accuracy of 83% was observed in differentiating follow-up patients with locoregional recurrent or second (or third) primary HNSCC from those without evidence of disease. CONCLUSION: This study has demonstrated the feasibility of using an e-nose to detect locoregional recurrent and/or second (or third) primary HNSCC"
Keywords:		"Aged Breath Tests Carcinoma, Squamous Cell/*diagnosis *Electronic Nose Feasibility Studies Female Head and Neck Neoplasms/*diagnosis Humans Male Middle Aged Neoplasm Recurrence, Local/*diagnosis Neoplasms, Second Primary/diagnosis Netherlands Neural Netwo;"
Notes:		"Medlinevan de Goor, Rens M G E Hardy, Joey C A van Hooren, Michel R A Kremer, Bernd Kross, Kenneth W eng 2019/04/24 Head Neck. 2019 Sep; 41(9):2983-2990. doi: 10.1002/hed.25787. Epub 2019 Apr 23"