| Title: | Biotechnological potential of insect fatty acid-modifying enzymes |
| Author(s): | Tupec M; Bucek A; Valterova I; Pichova I; |
| ISSN/ISBN: | 0939-5075 (Print) 0341-0382 (Linking) |
| Abstract: | "There are more than one million described insect species. This species richness is reflected in the diversity of insect metabolic processes. In particular, biosynthesis of secondary metabolites, such as defensive compounds and chemical signals, encompasses an extraordinarily wide range of chemicals that are generally unparalleled among natural products from other organisms. Insect genomes, transcriptomes and proteomes thus offer a valuable resource for discovery of novel enzymes with potential for biotechnological applications. Here, we focus on fatty acid (FA) metabolism-related enzymes, notably the fatty acyl desaturases and fatty acyl reductases involved in the biosynthesis of FA-derived pheromones. Research on insect pheromone-biosynthetic enzymes, which exhibit diverse enzymatic properties, has the potential to broaden the understanding of enzyme specificity determinants and contribute to engineering of enzymes with desired properties for biotechnological production of FA derivatives. Additionally, the application of such pheromone-biosynthetic enzymes represents an environmentally friendly and economic alternative to the chemical synthesis of pheromones that are used in insect pest management strategies" |
| Keywords: | Acyltransferases/genetics/*metabolism Animals Biosynthetic Pathways/genetics Biotechnology/*methods Fatty Acids/metabolism Insect Proteins/genetics/*metabolism Insecta/genetics/*metabolism Pheromones/metabolism fatty acyl desaturases fatty acyl reductases; |
| Notes: | "MedlineTupec, Michal Bucek, Ales Valterova, Irena Pichova, Iva eng Review Germany 2017/07/26 Z Naturforsch C J Biosci. 2017 Sep 26; 72(9-10):387-403. doi: 10.1515/znc-2017-0031" |
