| Title: | Does the last 20 years paradigm of clinical research using volatile organic compounds to non-invasively diagnose cancer need to change? Challenges and future direction |
| Author(s): | Tan SY; Ma Q; Li F; Jiang H; Peng XY; Dong J; Ye X; Wang QL; You FM; Fu X; Ren YF; |
| Address: | "Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan, China. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan, China. fuxi884853@163.com. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan, China. ryftcm.dr@yahoo.com" |
| DOI: | 10.1007/s00432-023-04940-7 |
| ISSN/ISBN: | 1432-1335 (Electronic) 0171-5216 (Linking) |
| Abstract: | "PURPOSE: Volatile organic compounds (VOCs) have shown great potential as novel biomarkers for cancer detection; however, comprehensive quantitative analysis is lacking. In this study, we performed a bibliometric analysis of non-invasive cancer diagnosis using VOCs to better characterise international trends and to predict future hotspots in this field, and then we focussed on human studies to analyse clinical characteristics for presenting the current controversies and future perspectives of further clinical work. METHODS: Publications, from 2002 to 2022, were retrieved from the Web of Science Core Collection database. CiteSpace and VOSviewer were used to generate network maps and identify the annual publications, top countries, authors, institutions, journals, references, and keywords. Then, we further screened clinical trials, and the key information was extracted into Microsoft Excel for further systematical analysis. RESULTS: Six hundred and forty-one articles were identified to evaluate research trends, of which 301 clinical trials were selected for further systematical analysis. Overall, the annual publications in this area increased, with an overall upward trend, while the quality of clinical research remains remarkably uneven. CONCLUSION: The study of non-invasive cancer diagnosis using VOCs would continue to be an active field. However, without stringent clinical design criteria, most suitable acquisition and analysis devices and statistical approaches, a list of exclusive, specific, reliable and reproducible VOCs to identify a disease and these VOCs appearing in a breath at detectable levels at early stage disease, the clinical utility of VOC tests will be difficult to have any breakthroughs" |
| Keywords: | "Humans *Volatile Organic Compounds *Neoplasms/diagnosis *Body Fluids Databases, Factual Bibliometric Cancer diagnosis Clinical studies Non-invasive technique Systematic review Volatile organic compounds;" |
| Notes: | "MedlineTan, Shi-Yan Ma, Qiong Li, Fang Jiang, Hua Peng, Xiao-Yun Dong, Jing Ye, Xin Wang, Qiao-Ling You, Feng-Ming Fu, Xi Ren, Yi-Feng eng 2022NSFSC0670/Qiao-Ling Wang/ 2022ZDZX0022/Feng-Ming You/ Review Germany 2023/06/05 J Cancer Res Clin Oncol. 2023 Sep; 149(12):10377-10386. doi: 10.1007/s00432-023-04940-7. Epub 2023 Jun 5" |
