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Sci Total Environ

Title:		Association between sum of volatile organic compounds and occurrence of building-related symptoms in humans: A study in real full-scale laboratory houses
Author(s):		Suzuki N; Nakaoka H; Nakayama Y; Tsumura K; Takaguchi K; Takaya K; Eguchi A; Hanazato M; Todaka E; Mori C;
Address:		"Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan. Electronic address: suzu-nori@chiba-u.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address: hnakaoka@faculty.chiba-u.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan. Electronic address: seiken@chiba-u.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan; Graduate School of Medical and Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address: tsumu-kayo@chiba-u.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan. Electronic address: k.takaguchi@chiba-u.jp. National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan. Electronic address: takaya-k@h.jniosh.johas.go.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan. Electronic address: a_eguchi@chiba-u.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan. Electronic address: hanazato@chiba-u.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address: todakae@faculty.chiba-u.jp. Center for Preventive Medical Sciences, Chiba University, 6-2-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address: cmori@faculty.chiba-u.jp"
Journal Title:		Sci Total Environ
Year:		2021
Volume:		20200815
Issue:
Page Number:		141635 -
DOI:		10.1016/j.scitotenv.2020.141635
ISSN/ISBN:		1879-1026 (Electronic) 0048-9697 (Linking)
Abstract:		"It is well known that the indoor environment, particularly indoor air quality (IAQ), has significant effects on building-related symptoms (BRSs) in humans, such as irritation of mucosal membranes, headaches, and allergies, such as asthma and atopic dermatitis. In 2017, Chiba University launched the 'Chemiless Town Project Phase 3' to investigate the relationship between IAQ and human health. Two laboratory houses (LHs) were built on a university campus in which the interiors and exteriors were similar, but the levels of indoor air volatile organic compounds (VOCs) were different. A total of 141 participants evaluated IAQ using their sensory perception. There was a significant relationship between differences in VOC levels and BRSs occurrence (OR: 6.89, 95% CI: 1.40-33.98). It was suggested that people with a medical history of allergies (OR: 5.73, 95% CI: 1.12-29.32) and those with a high sensitivity to chemicals (OR: 8.82, 95% CI: 1.16-67.16) tended to experience BRSs. Thus, when buildings are constructed, people with a history of allergies or with a sensitivity to chemicals may be at high risk to BRSs, and it is important to pay attention to IAQ to prevent BRSs"
Keywords:		"*Air Pollution, Indoor Humans Laboratories *Volatile Organic Compounds/analysis Allergy Chemiless Town Project Human health, laboratory houses Indoor air quality;"
Notes:		"MedlineSuzuki, Norimichi Nakaoka, Hiroko Nakayama, Yoshitake Tsumura, Kayo Takaguchi, Kohki Takaya, Kazunari Eguchi, Akifumi Hanazato, Masamichi Todaka, Emiko Mori, Chisato eng Netherlands 2020/09/04 Sci Total Environ. 2021 Jan 1; 750:141635. doi: 10.1016/j.scitotenv.2020.141635. Epub 2020 Aug 15"