| Title: | Association between maternal exposure to indoor air pollution and offspring congenital heart disease: a case-control study in East China |
| Author(s): | Sun J; Wang J; Yang J; Shi X; Li S; Cheng J; Chen S; Sun K; Wu Y; |
| Address: | "Department of Pediatric Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No. 1665 Kongjiang Road, Shanghai, 200092, China. Department of Fetal Echocardiography, Jiaxing Maternity and Child Health Care Hospital, No. 2468 Zhonghuan Dong Road, Jiaxing, 314051, China. School of Environmental Science and Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai, 200240, China. Department of Pediatric Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No. 1665 Kongjiang Road, Shanghai, 200092, China. sunkun@xinhuamed.com.cn. Department of Pediatric Cardiology, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, No. 1665 Kongjiang Road, Shanghai, 200092, China. wuyurong@xinhuamed.com.cn" |
| DOI: | 10.1186/s12889-022-13174-0 |
| ISSN/ISBN: | 1471-2458 (Electronic) 1471-2458 (Linking) |
| Abstract: | "BACKGROUND: Previous research suggested an association between maternal exposure to ambient air pollutants and the risk of congenital heart disease (CHD). However, the effect of individual prenatal exposure to indoor air pollutants on CHD occurrence was not reported. METHODS: We performed a hospital-based case-control study to investigate the association between personal air pollution exposure during pregnancy and the risk of CHD in offspring. A total of 44 cases and 75 controls were included from two hospitals in East China. We investigated maternal and residential environmental characteristics using a questionnaire and obtained personal indoor air samples to assess particulate matter (PM) and volatile organic compounds (VOCs) from 22-30 gestational weeks. Formaldehyde, benzene, toluene, xylene, total volatile organic compounds (TVOCs), PM(2.5), and PM(10) were assessed. Logistic regression was performed to assess associations and interactions between individual indoor air pollutants and CHD after adjusting for confounders. The potential residential environmental factors affecting the risks of indoor air pollutants on CHD were also assessed. RESULTS: Median TVOC (0.400 vs. 0.005 mg/m(3), P < 0.001) exposure levels in cases were significantly higher than controls. A logistic regression model adjusted for confounders revealed that exposure to high levels of indoor TVOCs (AOR 7.09, 95% CI 2.10-23.88) during pregnancy was associated with risks for CHD and the occurrence of some major CHD subtype in offspring. These risk effects were enhanced in pregnant women living in a newly renovated house but were mitigated by household use of smoke ventilators when cooking. We observed a positive interaction of maternal exposure to TVOCs and PM(2.5) and the risk for CHD. CONCLUSIONS: Maternal exposure to indoor VOCs and PMs may increase the risk of giving birth to foetuses with CHD" |
| Keywords: | "*Air Pollutants/adverse effects/analysis *Air Pollution *Air Pollution, Indoor/adverse effects/analysis Case-Control Studies China/epidemiology Female *Heart Defects, Congenital/epidemiology/etiology Humans Maternal Exposure/adverse effects Particulate Ma;" |
| Notes: | "MedlineSun, Jing Wang, Jian Yang, Jing Shi, Xin Li, Shujing Cheng, Jinping Chen, Sun Sun, Kun Wu, Yurong eng Research Support, Non-U.S. Gov't England 2022/04/17 BMC Public Health. 2022 Apr 15; 22(1):767. doi: 10.1186/s12889-022-13174-0" |
