| Title: | More than apples and oranges--detecting cancer with a fruit fly's antenna |
| Author(s): | Strauch M; Ludke A; Munch D; Laudes T; Galizia CG; Martinelli E; Lavra L; Paolesse R; Ulivieri A; Catini A; Capuano R; Di Natale C; |
| Address: | "1] Neurobiology, University of Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany [2]. Neurobiology, University of Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany. 1] Neurobiology, University of Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany [2] Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy. Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Roma, Italy. Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Via di Grottarossa 1035, 00189 Roma, Italy. Department of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Roma, Italy" |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated the potential of utilising the fruit fly's olfactory system to detect cancer cells. Using in vivo calcium imaging, we recorded an array of olfactory receptor neurons on the fruit fly's antenna. We performed multidimensional analysis of antenna responses, finding that cell volatiles from different cell types lead to characteristic response vectors. The distances between these response vectors are conserved across flies and can be used to discriminate healthy mammary epithelial cells from different types of breast cancer cells. This may expand the repertoire of clinical diagnostics, and it is the first step towards electronic noses equipped with biological sensors, integrating artificial and biological olfaction" |
| Keywords: | Animals Arthropod Antennae/*physiology Drosophila melanogaster/*physiology Humans Neoplasms/chemistry/*diagnosis Odorants Olfactory Receptor Neurons/*physiology Volatile Organic Compounds/analysis; |
| Notes: | "MedlineStrauch, Martin Ludke, Alja Munch, Daniel Laudes, Thomas Galizia, C Giovanni Martinelli, Eugenio Lavra, Luca Paolesse, Roberto Ulivieri, Alessandra Catini, Alexandro Capuano, Rosamaria Di Natale, Corrado eng Research Support, Non-U.S. Gov't England 2014/01/07 Sci Rep. 2014 Jan 6; 4:3576. doi: 10.1038/srep03576" |
