| Title: | HRMS directly from TLC slides. A powerful tool for rapid analysis of organic mixtures |
| Author(s): | Smith NJ; Domin MA; Scott LT; |
| Address: | "Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467-3860, USA" |
| ISSN/ISBN: | 1523-7052 (Electronic) 1523-7052 (Linking) |
| Abstract: | "High-resolution mass spectra (HRMS) of individual spots on thin-layer chromatography (TLC) slides can now be obtained quickly and easily at atmospheric pressure, with zero sample preparation, using commercially available instrumentation. The method is complementary to GC-mass spectrometry but is not limited to compounds of high volatility and high thermal stability. TLC-HRMS can be used to monitor chemical reactions in real time and has the capacity thereby to accelerate significantly the pace of synthetic organic chemistry" |
| Keywords: | "Chromatography, Thin Layer/instrumentation/*methods Mass Spectrometry/instrumentation/*methods *Membranes, Artificial Molecular Structure Organic Chemicals/*analysis Sensitivity and Specificity;" |
| Notes: | "MedlineSmith, Natalie J Domin, Marek A Scott, Lawrence T eng Research Support, Non-U.S. Gov't 2008/07/17 Org Lett. 2008 Aug 21; 10(16):3493-6. doi: 10.1021/ol8012759. Epub 2008 Jul 16" |
