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Math Biosci

Title:		Analysis of the absorption kinetics following dermal exposure to large doses of volatile organic compounds
Author(s):		Simon L;
Address:		"Otto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark NJ 07102, USA. Electronic address: laurent.simon@njit.edu"
Journal Title:		Math Biosci
Year:		2022
Volume:		20220819
Issue:
Page Number:		108889 -
DOI:		10.1016/j.mbs.2022.108889
ISSN/ISBN:		1879-3134 (Electronic) 0025-5564 (Linking)
Abstract:		"A mathematical method was developed to study the skin penetration of volatile organic compounds (VOCs) after exposure to a high dose of the substance. While closed-form solutions exist to describe the diffusion and evaporation from small amounts, numerical approaches are often implemented to predict dermal transport involving large doses. This work offers a Laplace transform-based method to estimate the time constant and dynamic and steady-state behaviors. First, the process was divided into two stages, separated by the time it took for excess chemicals to be depleted from the skin surface. Series solutions were written for the percutaneous VOC concentration, absorption and evaporation in the first stage. Application of Laplace transform methods yielded transient profiles after the compound dissipated from the surface of the stratum corneum. In addition, the procedure facilitated the calculation of the time constant and steady-state values. The method was validated using benchtop and fume hood experiments conducted with N,N-diethyl-3-methylbenzamide (DEET) and air velocities of 0.165 m/s and 0.72 m/s, respectively. The increase in the flow rate decreased the total amount of VOC absorbed and reduced the period required for the surface fluid to disappear"
Keywords:		Diffusion Kinetics Skin/metabolism *Skin Absorption *Volatile Organic Compounds/metabolism Absorption Effective time constant Evaporation Mathematical modeling Volatile organic compounds;
Notes:		"MedlineSimon, Laurent eng Research Support, U.S. Gov't, Non-P.H.S. 2022/08/22 Math Biosci. 2022 Sep; 351:108889. doi: 10.1016/j.mbs.2022.108889. Epub 2022 Aug 19"