| Title: | Mating and male pheromone kill Caenorhabditis males through distinct mechanisms |
| Author(s): | Shi C; Runnels AM; Murphy CT; |
| Address: | "Department of Molecular Biology and LSI Genomics, Princeton University, Princeton, United States" |
| ISSN/ISBN: | 2050-084X (Electronic) 2050-084X (Linking) |
| Abstract: | "Differences in longevity between sexes is a mysterious yet general phenomenon across great evolutionary distances. To test the roles of responses to environmental cues and sexual behaviors in longevity regulation, we examined Caenorhabditis male lifespan under solitary, grouped, and mated conditions. We find that neurons and the germline are required for male pheromone-dependent male death. Hermaphrodites with a masculinized nervous system secrete male pheromone and are susceptible to male pheromone killing. Male pheromone-mediated killing is unique to androdioecious Caenorhabditis, and may reduce the number of males in hermaphroditic populations; neither males nor females of gonochoristic species are susceptible to male pheromone killing. By contrast, mating-induced death, which is characterized by germline-dependent shrinking, glycogen loss, and ectopic vitellogenin expression, utilizes distinct molecular pathways and is shared between the sexes and across species. The study of sex- and species-specific regulation of aging reveals deeply conserved mechanisms of longevity and population structure regulation" |
| Keywords: | "Animals Caenorhabditis/*physiology *Longevity Male Pheromones/*metabolism *Sexual Behavior, Animal C.elegans Caenorhabditis aging developmental biology evolutionary biology genomics germline mating pheromone stem cells;" |
| Notes: | "MedlineShi, Cheng Runnels, Alexi M Murphy, Coleen T eng DP1 GM119167/GM/NIGMS NIH HHS/ R01 AG034446/AG/NIA NIH HHS/ T32 GM007388/GM/NIGMS NIH HHS/ HHMI/Howard Hughes Medical Institute/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2017/03/16 Elife. 2017 Mar 14; 6:e23493. doi: 10.7554/eLife.23493" |
