« Previous AbstractGypsy moth pheromone-binding protein-ligand interactions: pH profiles and simulations as tools for detecting polar interactions    Next AbstractElectronic Cigarettes and Vaping-Associated Lung Injury (EVALI): A Rural Appalachian Experience »

Acta Parasitol

Title:		Manipulation by Plasmodium Parasites of Anopheles Mosquito Behavior and Human Odors
Author(s):		Sanford T; Shutler D;
Address:		"Department of Biology, Acadia University, Wolfville, NS, B4P 2R6, Canada. Department of Biology, Acadia University, Wolfville, NS, B4P 2R6, Canada. dave.shutler@acadiau.ca"
Journal Title:		Acta Parasitol
Year:		2022
Volume:		20221019
Issue:		4
Page Number:		1463 - 1470
DOI:		10.1007/s11686-022-00621-6
ISSN/ISBN:		1896-1851 (Electronic) 1230-2821 (Linking)
Abstract:		"PURPOSE: The phenomenon of parasites manipulating host phenotypes is well documented; the best-known examples are manipulations of host behavior. More recently, there has been interest in whether parasites can manipulate host odor phenotypes to enhance their attractiveness to vectors. We review here evidence that Plasmodium-infected mosquitoes have enhanced attraction to human hosts, especially when the parasite is sufficiently developed to be transmissible. We also review evidence suggesting that malaria-infected host odors elicit greater mosquito attraction compared to uninfected controls. METHODS: We reviewed and summarized the relevant literature. RESULTS: Though evidence is mounting that supports both premises we reviewed, there are several confounds that complicate interpretation. These include differences in Plasmodium and mosquito species studied, stage of infection tested, age of human participants in trials, and methods used to quantify volatiles. In addition, a key requirement to support the hypothesis of manipulation by parasites is that costs of manipulation be identified, and ideally, quantified. CONCLUSIONS: Substantial progress has been made to unlock the importance of odor for enhancing transmission of Plasmodium. However, there needs to be more replication using similar methods to better define the odor parameters involved in this enhancement"
Keywords:		Animals Humans *Anopheles/parasitology Odorants *Parasites Mosquito Vectors/parasitology *Plasmodium Feeding Behavior Malaria Manipulation of host odor Transmissible stages Volatile organic compounds;
Notes:		"MedlineSanford, Tristan Shutler, Dave eng Review Switzerland 2022/10/20 Acta Parasitol. 2022 Dec; 67(4):1463-1470. doi: 10.1007/s11686-022-00621-6. Epub 2022 Oct 19"