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MicroPubl Biol

Title:		The Architect of Neurotransmission in C. elegans : How FLP-3 Neuropeptides' Structures Direct their Function
Author(s):		Salama R; DiLoreto E; Srinivasan J;
Address:		"Biology and Biotechnology, Worcester Polytechnic Institute. Neuroscience Program, Worcester Polytechnic Institute"
Journal Title:		MicroPubl Biol
Year:		2023
Volume:		20230527
Issue:
Page Number:		-
DOI:		10.17912/micropub.biology.000829
ISSN/ISBN:		2578-9430 (Electronic) 2578-9430 (Linking)
Abstract:		"Neuropeptides direct functions in the nervous, endocrine, and immune systems of all animals by altering the activity at neural synapses. A single neuropeptide gene can be post-translationally modified to create multiple active peptides. These individual active peptides can have unique functions and drive discrete binding partners. We have previously shown that specific peptides encoded by the C. elegans neuropeptide gene, flp- 3, have sex-specific roles in response to a pheromone released by hermaphrodite C. elegans, ascaroside #8 (ascr#8). Using structural predictions of select FLP-3 neuropeptides, we identify individual amino acids within specific neuropeptides that regulate specific behaviors suggesting structure-function relationships of neuropeptides in regulate sex-specific behaviors"
Keywords:
Notes:		"PubMed-not-MEDLINESalama, Rehab DiLoreto, Elizabeth Srinivasan, Jagan eng R01 DC016058/DC/NIDCD NIH HHS/ 2023/07/03 MicroPubl Biol. 2023 May 27; 2023:10.17912/micropub.biology.000829. doi: 10.17912/micropub.biology.000829. eCollection 2023"