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Med Hypotheses

Title:		Does salivary protein(s) act an ovulation indicator for women? A hypothesis
Author(s):		Saibaba G; Archunan G;
Address:		"Centre for Pheromone Technology, Department of Animal Science, Bharathidasan University, Tiruchirappalli 620024, India. Centre for Pheromone Technology, Department of Animal Science, Bharathidasan University, Tiruchirappalli 620024, India. Electronic address: garchu56@yahoo.co.in"
Journal Title:		Med Hypotheses
Year:		2015
Volume:		20141215
Issue:		2
Page Number:		104 - 106
DOI:		10.1016/j.mehy.2014.12.009
ISSN/ISBN:		1532-2777 (Electronic) 0306-9877 (Linking)
Abstract:		"Ovulation is an important physiological process in human, and its effect may reflect in body fluids via secretion of biomolecules such as proteins, amino acids, antioxidants, antimicrobial peptides and so on. Recently, the non-invasive sampling approaches are used to diagnose disease status and access health condition of human. Saliva comprises various proteins which are secreted through salivary glands. The proteins present in the saliva may vary in their expression according to the hormonal level and physiological nature of the body which are said to be hormone receptors, stress proteins and antimicrobial peptides. Therefore, it is postulated that saliva can be used in the detection of ovulation time in human using specific protein(s) expression and which can be considered as a best non-invasive method. The identification of these proteins by adopting LC-MS/MS followed by Western blot analysis are possible to identify a promising biomarker for ovulation detection in human"
Keywords:		"Biomarkers/*metabolism Blotting, Western/methods Chromatography, Liquid/methods Female Humans *Models, Biological Ovulation Detection/*methods Salivary Proteins and Peptides/*metabolism Tandem Mass Spectrometry/methods;"
Notes:		"MedlineSaibaba, Ganesan Archunan, Govindaraju eng Research Support, Non-U.S. Gov't 2015/01/06 Med Hypotheses. 2015 Feb; 84(2):104-6. doi: 10.1016/j.mehy.2014.12.009. Epub 2014 Dec 15"