« Previous Abstract"Functional characterization of the epoxidase gene, Li_epo1 (CYP341B14), involved in generation of epoxyalkene pheromones in the mulberry tiger moth Lemyra imparilis"    Next Abstract"Concentration-dependent parsimonious releaser roles of gregarious male pheromone of the desert locust, Schistocerca gregaria" »

Rev Iberoam Micol

Title:		Genomics of Aspergillus fumigatus
Author(s):		Ronning CM; Fedorova ND; Bowyer P; Coulson R; Goldman G; Kim HS; Turner G; Wortman JR; Yu J; Anderson MJ; Denning DW; Nierman WC;
Address:		"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. cronning@tigr.org"
Journal Title:		Rev Iberoam Micol
Year:		2005
Volume:		22
Issue:		4
Page Number:		223 - 228
DOI:		10.1016/s1130-1406(05)70047-4
ISSN/ISBN:		1130-1406 (Print) 1130-1406 (Linking)
Abstract:		"Aspergillus fumigatus is a filamentous fungal saprophyte that is ubiquitous in the environment. It is also a human pathogen and induces allergenic response, negatively impacting health care and associated costs significantly around the world. Much of the basic biology of this organism is only poorly understood, but the recent completion and publication of its genome sequence provides an excellent tool for researchers to gain insight into these processes. In this review we will summarize some of the more salient features revealed by analysis of the genome, including the search for candidate pathogenicity genes and the switch to a pathogenic lifestyle, allergen proteins, DNA repair, secondary metabolite gene clusters that produce compounds both useful and toxic, a theoretical capability of this asexual organism to reproduce sexually, signalling, and transcription. A. fumigatus was compared with the food biotechnology fungus Aspergillus oryzae and sexual fungus Aspergillus nidulans, as well as other fungi, in an attempt to discern key differences between these organisms"
Keywords:		"Allergens/genetics/immunology Aspergillosis/microbiology Aspergillus fumigatus/*genetics/immunology/pathogenicity Asthma/etiology Chromosomes, Fungal/genetics Genes, Fungal *Genome, Fungal Humans Pheromones/genetics Reproduction/genetics Signal Transducti;"
Notes:		"MedlineRonning, Catherine M Fedorova, Natalie D Bowyer, Paul Coulson, Richard Goldman, Gustavo Kim, H Stanley Turner, Geoffrey Wortman, Jennifer R Yu, Jiujiang Anderson, Michael J Denning, David W Nierman, William C eng Review Spain 2006/02/28 Rev Iberoam Micol. 2005 Dec; 22(4):223-8. doi: 10.1016/s1130-1406(05)70047-4"