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Curr Oncol

Title:		Differences in the Volatilomic Urinary Biosignature of Prostate Cancer Patients as a Feasibility Study for the Detection of Potential Biomarkers
Author(s):		Riccio G; Berenguer CV; Perestrelo R; Pereira F; Berenguer P; Ornelas CP; Sousa AC; Vital JA; Pinto MDC; Pereira JAM; Greco V; Camara JS;
Address:		"Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Univesita Cattolica del Sacro Cuore, 00168 Rome, Italy. Unity of Chemistry, Biochemistry and Clinical Molecular Biology, Department of Diagnostic and Laboratory Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy. CQM-Centro de Quimica da Madeira, NPRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal. Servico de Urologia, Hospital Dr. Nelio Mendonca, SESARAM, EPERAM-Servico de Saude da Regiao Autonoma da Madeira, Avenida Luis de Camoes, n masculine57, 9004-514 Funchal, Portugal. Centro de Investigacao Dra Maria Isabel Mendonca, Hospital Dr. Nelio Mendonca, SESARAM, EPERAM, Avenida Luis de Camoes, n masculine57, 9004-514 Funchal, Portugal. RO-RAM-Registo Oncologico da Regiao Autonoma da Madeira, Hospital Dr. Nelio Mendonca, SESARAM, EPERAM, Avenida Luis de Camoes, n masculine57, 9004-514 Funchal, Portugal. Centro de Saude do Bom Jesus, SESARAM, EPERAM, Rua das Hortas, n masculine67, 9050-024 Funchal, Portugal. Departamento de Quimica, Faculdade de Ciencias Exatas e Engenharia, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"
Journal Title:		Curr Oncol
Year:		2023
Volume:		20230510
Issue:		5
Page Number:		4904 - 4921
DOI:		10.3390/curroncol30050370
ISSN/ISBN:		1718-7729 (Electronic) 1198-0052 (Print) 1198-0052 (Linking)
Abstract:		"Prostate cancer (PCa) continues to be the second most common malignant tumour and the main cause of oncological death in men. Investigating endogenous volatile organic metabolites (VOMs) produced by various metabolic pathways is emerging as a novel, effective, and non-invasive source of information to establish the volatilomic biosignature of PCa. In this study, headspace solid-phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME/GC-MS) was used to establish the urine volatilomic profile of PCa and identify VOMs that can discriminate between the two investigated groups. This non-invasive approach was applied to oncological patients (PCa group, n = 26) and cancer-free individuals (control group, n = 30), retrieving a total of 147 VOMs from various chemical families. This included terpenes, norisoprenoid, sesquiterpenes, phenolic, sulphur and furanic compounds, ketones, alcohols, esters, aldehydes, carboxylic acid, benzene and naphthalene derivatives, hydrocarbons, and heterocyclic hydrocarbons. The data matrix was subjected to multivariate analysis, namely partial least-squares discriminant analysis (PLS-DA). Accordingly, this analysis showed that the group under study presented different volatomic profiles and suggested potential PCa biomarkers. Nevertheless, a larger cohort of samples is required to boost the predictability and accuracy of the statistical models developed"
Keywords:		"Male Humans *Volatile Organic Compounds/analysis Feasibility Studies Biomarkers Terpenes *Neoplasms, Second Primary *Prostatic Neoplasms prostate cancer urine volatilomics;"
Notes:		"MedlineRiccio, Giulia Berenguer, Cristina V Perestrelo, Rosa Pereira, Ferdinando Berenguer, Pedro Ornelas, Cristina P Sousa, Ana Celia Vital, Joao Aragao Pinto, Maria do Carmo Pereira, Jorge A M Greco, Viviana Camara, Jose S eng Research Support, Non-U.S. Gov't Switzerland 2023/05/26 Curr Oncol. 2023 May 10; 30(5):4904-4921. doi: 10.3390/curroncol30050370"