| Title: | Analogous telesensing pathways regulate mating and virulence in two opportunistic human pathogens |
| Address: | "Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA. richard_bennett@brown.edu" |
| Abstract: | "Telesensing, or probing of the environment by the release of chemical messengers, plays a central role in the sexual programs of microbial organisms. Sex pheromones secreted by mating cells are sensed by potential partner cells and mediate cell-to-cell contact and the subsequent exchange of genetic material. Although the mechanisms used by bacterial and fungal species to promote genetic exchange are distinct, recent studies have uncovered surprising parallels between pheromone signaling in these species. In addition, it is now apparent that pheromone signaling not only controls sexual reproduction and genetic exchange but can also activate expression of potential virulence factors in diverse opportunistic pathogens" |
| Keywords: | "Animals Candida albicans/genetics/*pathogenicity/physiology Candidiasis/*microbiology *Conjugation, Genetic Enterococcus faecalis/genetics/*pathogenicity/physiology Gram-Positive Bacterial Infections/*microbiology Humans Pheromones/*metabolism Reproductio;" |
| Notes: | "MedlineBennett, Richard J Dunny, Gary M eng R01 AI058134-06A1/AI/NIAID NIH HHS/ 2R01AI058134/AI/NIAID NIH HHS/ 2R01GM049530/GM/NIGMS NIH HHS/ R21 AI081560/AI/NIAID NIH HHS/ R56 AI058134/AI/NIAID NIH HHS/ R01 GM049530/GM/NIGMS NIH HHS/ R56 AI058134-06/AI/NIAID NIH HHS/ R01AI081704/AI/NIAID NIH HHS/ R01 AI058134/AI/NIAID NIH HHS/ R21AI081560/AI/NIAID NIH HHS/ R01 GM049530-26A1/GM/NIGMS NIH HHS/ R01 AI081704/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review 2010/09/10 mBio. 2010 Sep 7; 1(4):e00181-10. doi: 10.1128/mBio.00181-10" |
