| Title: | Exploring alternative insecticide delivery options in a 'lethal house lure' for malaria vector control |
| Author(s): | Oumbouke WA; Barreaux AMG; Zran IT; Koffi AA; N'Guessan Y; Alou LPA; Wolie RZ; Cook J; Sternberg ED; Thomas MB; N'Guessan R; |
| Address: | "Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK. welbeck.oumbouke@ivcc.com. Innovative Vector Control Consortium, IVCC, Liverpool, UK. welbeck.oumbouke@ivcc.com. Institut Pierre Richet (IPR)/Institut National de Sante Publique (INSP), Bouake, Cote d'Ivoire. welbeck.oumbouke@ivcc.com. Department of Entomology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA, 16802, USA. Animal Health Theme, ICIPE, Nairobi, Kenya. CIRAD, UMR INTERTRYP, 34398, Montpellier, France. CIRAD, IRD, INTERTRYP, Univ Montpellier, 34000, Montpellier, France. Institut Pierre Richet (IPR)/Institut National de Sante Publique (INSP), Bouake, Cote d'Ivoire. Unite de Recherche et de Pedagogie de Genetique, UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. Medical Research Council (MRC) International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK. Tropical Health LLP, London, UK. Entomology and Nematology Department, University of Florida, Gainesville, USA. Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK" |
| DOI: | 10.1038/s41598-023-31116-7 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "The In2Care EaveTube is a house modification designed to block and kill malaria mosquitoes using an electrostatic netting treated with insecticide powder. A previous study demonstrated prolonged duration of effective action of insecticide-treated electrostatic netting in a semi-field setting. As part of a cluster randomized controlled trial (CRT) of the EaveTube intervention in Cote d'Ivoire, we investigated the residual efficacy of a pyrethroid insecticide deployed in EaveTubes under village conditions of use. We also explored the scope of using existing malaria control technologies including LLINs and IRS as alternative methods to deliver insecticides in the lethal house lure. The efficacy of beta-cyfluthrin was monitored over time using the 'eave tube bioassay' method. Mortality of beta-cyfluthrin exposed pyrethroid resistant Anopheles gambiae mosquitoes was > 80% after 4 months. The impact (mosquito mortality) of PVC tubes coated with pirimiphos methyl was similar to that of beta-cyfluthrin treated insert (66.8 vs. 62.8%) in release-recapture experiments in experimental huts. Efficacy was significantly lower with all the LLINs tested; however, the roof of PermaNet 3.0 induced significantly higher mosquito mortality (50.4%) compared to Olyset Plus (25.9%) and Interceptor G2 (21.6%) LLINs. The efficacy of the alternative delivery methods was short-lived with mortality decreasing below 50% within 2 months in residual activity bioassays. None of the products tested appeared superior to the powder treatments. Further research is therefore required to identify suitable insecticide delivery options in EaveTube for malaria vector control" |
| Keywords: | Animals *Insecticides/pharmacology *Anopheles Mosquito Control/methods Powders/pharmacology Mosquito Vectors *Malaria/prevention & control *Pyrethrins/pharmacology Insecticide Resistance *Insecticide-Treated Bednets; |
| Notes: | "MedlineOumbouke, Welbeck A Barreaux, Antoine M G Zran, Innocent T Koffi, Alphonsine A N'Guessan, Yao Alou, Ludovic P Ahoua Wolie, Rosine Z Cook, Jackie Sternberg, Eleanore D Thomas, Matthew B N'Guessan, Raphael eng Randomized Controlled Trial Research Support, Non-U.S. Gov't England 2023/03/26 Sci Rep. 2023 Mar 24; 13(1):4820. doi: 10.1038/s41598-023-31116-7" |
