| Title: | "Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination" |
| Author(s): | Opletal L; Sovova H; Bartlova M; |
| Address: | "Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, CZ-50005 Hradec Kralove, Czech Republic" |
| Journal Title: | J Chromatogr B Analyt Technol Biomed Life Sci |
| DOI: | 10.1016/j.jchromb.2004.07.040 |
| ISSN/ISBN: | 1570-0232 (Print) 1570-0232 (Linking) |
| Abstract: | "The drug Wuweizi (dried fruits of Schisandra chinensis or S. sphenantherd) is one of important medicinal means used in the Oriental medicine. The lignans of dibenzo[a,c]cyklooctadiene type are major constituents, a volatile oil with mono- and ses-quiterpens, an oil, organic acids and small amounts of additional compounds are also present. The content of major lignans (schizandrin, deoxyschizandrin, gomisin A, gomisin N, gamma-schizandrin, wuweizisu C) in commercially available drugs ranges usually between 3 and 5%. The present paper biefly comments the isolation and biological activity of the lignans and is especially concerned with analytical methods (TLC and HPLC) for the determination of the drug fingerprint and methods for the determination of constituents in drugs, mixtures and biological materials. HPLC methods using RP-silica bonded phases and diluted methanol, acetonitrile (or a mixture of both), are most important for these purposes. Electromigration methods are less suitable and the importance of hyphenation procedures is practically negligible" |
| Keywords: | "Chromatography, High Pressure Liquid Chromatography, Thin Layer Cyclooctanes/*chemistry Lignans/chemistry/*isolation & purification Schisandra/*chemistry;" |
| Notes: | "MedlineOpletal, Lubomir Sovova, Helena Bartlova, Milena eng Research Support, Non-U.S. Gov't Netherlands 2004/11/24 J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 5; 812(1-2):357-71. doi: 10.1016/j.jchromb.2004.07.040" |
