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Sci Rep

Title:		Imorin: a sexual attractiveness pheromone in female red-bellied newts (Cynops pyrrhogaster)
Author(s):		Nakada T; Toyoda F; Matsuda K; Nakakura T; Hasunuma I; Yamamoto K; Onoue S; Yokosuka M; Kikuyama S;
Address:		"Department of Veterinary Medicine, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan. Department of Physiology, Nara Medical University, Nara 634-8521, Japan. Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan. Department of Anatomy and Cell Biology, Teikyo University School of Medicine, Tokyo 173-8605, Japan. Department of Biology, Faculty of Science, Toho University, Chiba 274-8510, Japan. Department of Biology, Faculty of Education and Integrated Sciences, Waseda University, Tokyo 169-8050, Japan. Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan"
Journal Title:		Sci Rep
Year:		2017
Volume:		20170125
Issue:
Page Number:		41334 -
DOI:		10.1038/srep41334
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"The male red-bellied newt (Cynops pyrrhogaster) approaches the female's cloaca prior to performing any courtship behaviour, as if he is using some released substance to gauge whether she is sexually receptive. Therefore, we investigated whether such a female sexual attractiveness pheromone exists. We found that a tripeptide with amino acid sequence Ala-Glu-Phe is secreted by the ciliary cells in the epithelium of the proximal portion of the oviduct of sexually developed newts and confirmed that this is the major active substance in water in which sexually developed female newts have been kept. This substance only attracted sexually developed male newts and acted by stimulating the vomeronasal epithelial cells. This is the first female sexual attractiveness peptide pheromone to be identified in a vertebrate"
Keywords:		Animals Dipeptides/isolation & purification/pharmacology Female Male Oviducts/cytology/drug effects/ultrastructure Salamandridae/*physiology Sex Attractants/isolation & purification/*pharmacology Vomeronasal Organ/cytology;
Notes:		"MedlineNakada, Tomoaki Toyoda, Fumiyo Matsuda, Kouhei Nakakura, Takashi Hasunuma, Itaru Yamamoto, Kazutoshi Onoue, Satomi Yokosuka, Makoto Kikuyama, Sakae eng Research Support, Non-U.S. Gov't England 2017/01/26 Sci Rep. 2017 Jan 25; 7:41334. doi: 10.1038/srep41334"