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J Assist Reprod Genet

Title:		Air quality in the assisted reproduction laboratory: a mini-review
Author(s):		Morbeck DE;
Address:		"Division of Reproductive Endocrinology and Infertility, Division of Laboratory Genetics, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA, morbeck.dean@mayo.edu"
Journal Title:		J Assist Reprod Genet
Year:		2015
Volume:		20150804
Issue:		7
Page Number:		1019 - 1024
DOI:		10.1007/s10815-015-0535-x
ISSN/ISBN:		1573-7330 (Electronic) 1058-0468 (Print) 1058-0468 (Linking)
Abstract:		"Quality of air in the clinical embryology laboratory is considered critical for high in vitro fertilization (IVF) success rates, yet evidence for best practices is lacking. Predominantly anecdotal reports on relationships between air quality and IVF success rates have resulted in minimal authentic clinical laboratory guidelines or in recommendations that are based on industrial cleanroom particulate standards with little attention to chemical air filtration. As a result, a nascent industry of costly, specialized air handling equipment for IVF laboratories has emerged to provide air quality solutions that have not been clearly assessed or verified. Clinics are embracing such technology because their embryology laboratories have become epicenters of assisted reproductive technology as the practice of IVF has moved to blastocyst transfers and utilization of trophectoderm biopsy for preimplantation genetic testing (PGT). Thus, a laboratory's ability to culture, biopsy, and freeze blastocysts is a rate-limiting step that depends on technical proficiency and a supportive and stable culture environment based on a foundation of high-quality ambient air. This review aims to describe how evidence for the importance of air quality, in particular the role of volatile organic compounds (VOC), has resulted in an evolution of clinical practice that has arguably contributed to improved outcomes"
Keywords:		"Air Pollution, Indoor/*adverse effects Embryo Transfer/methods Female Fertilization in Vitro Filtration/instrumentation/methods Humans Laboratories/*standards Pregnancy Reproductive Techniques, Assisted/*standards Treatment Outcome Volatile Organic Compou;"
Notes:		"MedlineMorbeck, Dean E eng Review Netherlands 2015/08/05 J Assist Reprod Genet. 2015 Jul; 32(7):1019-24. doi: 10.1007/s10815-015-0535-x. Epub 2015 Aug 4"