| Title: | Effect of nasal instillation of female urine or vaginal exudate on testosterone secretion in isolated and anesthetized male rhesus monkeys (Macaca mulatta) |
| Author(s): | Mora OA; Garcia Castineiras S; Guisado S; Ezquerra C; |
| Address: | "Departamento de Fisiologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain" |
| DOI: | 10.1016/0024-3205(90)90335-o |
| ISSN/ISBN: | 0024-3205 (Print) 0024-3205 (Linking) |
| Abstract: | "Two male adult rhesus monkeys were individually placed in cages with a pulling device in order to immobilize the animals for anesthesia. The room was temperature-controlled having a light/dark period of 12/12 hours. The animals were rapidly immobilized and immediately anesthetized with ketamine i. m. (10 mg/kg of body weight). They were bled four times at 15, 30, 45, and 60 mins after the ketamine injection, twice a week during 6 weeks. When necessary, maintenance doses of ketamine were administered. The levels of serum testosterone in experimental conditions (nasal instillation of female urine or a suspension of vaginal exudate) showed significant lower values with respect to those in control conditions (saline instillation). The control levels of testosterone tend to increase up to 60 mins. The testosterone from samples obtained in experimental conditions did not show such an increase, remaining similar during the sampling and similar to the 15 min control levels that could be considered as basal. These results seem to point out some chemical information from females capable of modifying the pattern of secretion of testosterone of the males in the above mentioned experimental conditions" |
| Keywords: | "Administration, Intranasal Analysis of Variance Anesthesia Animals Exudates and Transudates/*physiology Female Macaca mulatta Male Pheromones/*physiology Testosterone/*metabolism Urine/*physiology Vagina/*physiology;" |
| Notes: | "MedlineMora, O A Garcia Castineiras, S Guisado, S Ezquerra, C eng RR 05419-27/RR/NCRR NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Netherlands 1990/01/01 Life Sci. 1990; 46(19):1359-65. doi: 10.1016/0024-3205(90)90335-o" |
