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Front Neurol

Title:		A Distinct Metabolite Signature in Military Personnel Exposed to Repetitive Low-Level Blasts
Author(s):		Miller MR; DiBattista A; Patel MA; Daley M; Tenn C; Nakashima A; Rhind SG; Vartanian O; Shiu MY; Caddy N; Garrett M; Saunders D; Smith I; Jetly R; Fraser DD;
Address:		"Lawson Health Research Institute, London, ON, Canada. Department of Pediatrics, Western University, London, ON, Canada. Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. Neurolytix Inc., Toronto, ON, Canada. Department of Computer Science, Western University, London, ON, Canada. The Vector Institute for Artificial Intelligence, Toronto, ON, Canada. Defence Research and Development Canada, Suffield Research Centre, Medicine Hat, AB, Canada. Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, Canada. Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada. Department of Psychology, University of Toronto, Toronto, ON, Canada. Canadian Forces Health Services, National Defence Headquarters, Ottawa, ON, Canada. Department of Psychiatry, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada. Clinical Neurological Sciences, Western University, London, ON, Canada. Physiology and Pharmacology, Western University, London, ON, Canada"
Journal Title:		Front Neurol
Year:		2022
Volume:		20220407
Issue:
Page Number:		831792 -
DOI:		10.3389/fneur.2022.831792
ISSN/ISBN:		1664-2295 (Print) 1664-2295 (Electronic) 1664-2295 (Linking)
Abstract:		"Military Breachers and Range Staff (MBRS) are subjected to repeated sub-concussive blasts, and they often report symptoms that are consistent with a mild traumatic brain injury (mTBI). Biomarkers of blast injury would potentially aid blast injury diagnosis, surveillance and avoidance. Our objective was to identify plasma metabolite biomarkers in military personnel that were exposed to repeated low-level or sub-concussive blast overpressure. A total of 37 military members were enrolled (18 MBRS and 19 controls), with MBRS having participated in 8-20 breaching courses per year, with a maximum exposure of 6 blasts per day. The two cohorts were similar except that the number of blast exposures were significantly higher in the MBRS, and the MBRS cohort suffered significantly more post-concussive symptoms and poorer health on assessment. Metabolomics profiling demonstrated significant differences between groups with 74% MBRS classification accuracy (CA). Feature reduction identified 6 metabolites that resulted in a MBRS CA of 98%, and included acetic acid (23.7%), formate (22.6%), creatine (14.8%), acetone (14.2%), methanol (12,7%), and glutamic acid (12.0%). All 6 metabolites were examined with individual receiver operating characteristic (ROC) curve analyses and demonstrated areas-under-the-curve (AUCs) of 0.82-0.91 (P
Keywords:		biomarkers blast metabolites mild traumatic brain injury military;
Notes:		"PubMed-not-MEDLINEMiller, Michael R DiBattista, Alicia Patel, Maitray A Daley, Mark Tenn, Catherine Nakashima, Ann Rhind, Shawn G Vartanian, Oshin Shiu, Maria Y Caddy, Norleen Garrett, Michelle Saunders, Doug Smith, Ingrid Jetly, Rakesh Fraser, Douglas D eng Switzerland 2022/04/26 Front Neurol. 2022 Apr 7; 13:831792. doi: 10.3389/fneur.2022.831792. eCollection 2022"