« Previous AbstractIn vitro toxicological evaluation of emissions from catalytic oxidation removal of industrial VOCs by air/liquid interface (ALI) exposure system in repeated mode    Next AbstractInflammation interferes with chemoreception in pigs by altering the neuronal layout of the vomeronasal sensory epithelium »

Animals (Basel)

Title:		Histological and Immunohistochemical Characterization of Vomeronasal Organ Aging in Mice
Author(s):		Mechin V; Pageat P; Teruel E; Asproni P;
Address:		"Tissue Biology and Chemical Communication Department, IRSEA, Institute of Research in Semiochemistry and Applied Ethology, 84400 Apt, France. Research and Education Board, IRSEA, Institute of Research in Semiochemistry and Applied Ethology, 84400 Apt, France. Statistics and Data Management Service, IRSEA, Institute of Research in Semiochemistry and Applied Ethology, 84400 Apt, France"
Journal Title:		Animals (Basel)
Year:		2021
Volume:		20210422
Issue:		5
Page Number:		-
DOI:		10.3390/ani11051211
ISSN/ISBN:		2076-2615 (Print) 2076-2615 (Electronic) 2076-2615 (Linking)
Abstract:		"The vomeronasal organ (VNO) plays a crucial role in animal behavior since it is responsible for semiochemical detection and, thus, for intra- and interspecific chemical communication, through the vomeronasal sensory epithelium (VNSE), composed of bipolar sensory neurons. This study aimed to explore a well-recognized cause of neuronal degeneration, only rarely explored in this organ: aging. Murine VNOs were evaluated according to 3 age groups (3, 10, and 24 months) by histology to assess VNSE changes such as cellular degeneration or glycogen accumulation and by immunohistochemistry to explore nervous configuration, proliferation capability, and apoptosis with the expression of olfactory marker protein (OMP), Galphai2, Galphao, Ki-67, and cleaved caspase-3 proteins. These markers were quantified as percentages of positive signal in the VNSE and statistical analyses were performed. Cellular degeneration increased with age (p < 0.0001) as well as glycogen accumulation (p < 0.0001), Galphao expression (p < 0.0001), and the number of cleaved-caspase3 positive cells (p = 0.0425), while OMP and Galphai2 expressions decreased with age (p = 0.0436 and p < 0.0001, respectively). Ki67-positive cells were reduced, even if this difference was not statistically significant (p = 0.9105). Due to the crucial role of VNO in animal life, this study opens the door to interesting perspectives about chemical communication efficiency in aging animals"
Keywords:		aging chemoreception histology pathology vomeronasal organ;
Notes:		"PubMed-not-MEDLINEMechin, Violaine Pageat, Patrick Teruel, Eva Asproni, Pietro eng Switzerland 2021/05/01 Animals (Basel). 2021 Apr 22; 11(5):1211. doi: 10.3390/ani11051211"