« Previous AbstractMulti-residue contaminants and pollutants analysis in saffron spice by stir bar sorptive extraction and gas chromatography-ion trap tandem mass spectrometry    Next AbstractExperience-based vocalization of male mice to female chemosignals »

Curr Pharm Des

Title:		Essential Oils and Pure Volatile Compounds as Potential Drugs in Alzheimer's Disease Therapy: An Updated Review of the Literature
Author(s):		Maggio A; Rosselli S; Bruno M;
Address:		"Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Parco d'Orleans II - 90128 Palermo, Italy. antonella.maggio@unipa.it"
Journal Title:		Curr Pharm Des
Year:		2016
Volume:		22
Issue:		26
Page Number:		4011 - 4027
DOI:		10.2174/1381612822666160607065917
ISSN/ISBN:		1873-4286 (Electronic) 1381-6128 (Linking)
Abstract:		"BACKGROUND: The use of aromatic plants to relief different illness is not a new therapy. Actually aromatic plants have been used for many centuries by different cultures around the world. Pharmacological studies provide scientific support to the traditional use of aromatic medicinal plants and aromatherapy; nevertheless, more clinical trials are required regarding to their effectiveness in order to establish a guidance for their use in routine healthcare. Moreover, modern medicine in studies about olfactory function has attained great achievements and got Nobel Prize in 2004. These new searches have obviously fueled interest in the essential oils and volatile compounds of natural origin. Several reviews on the newly discovered AChEi obtained from plants, fungus and marine organisms have also been published over the last years. The majority of these AChEi belong to the alkaloid group, including indole, isoquinoline, quinolizidine, piperidine and steroidal alkaloids. RESULTS: Probably the interest in the essential oils and volatile compounds will be fueled from the new available scientific data about receptor on olfactory mucosa of nasal cavity. It can receive and distinguish different odor molecules, which produce nerve impulse and transmit into olfactory bulb via olfactory nerves. The nerve cells in the olfactory bulb transmit the signals into hippocampus. Because hippocampus is closely related with learning and memory functions, the volatile compounds can be potential drugs in AD therapies"
Keywords:		"Alzheimer Disease/*drug therapy Animals Humans Oils, Volatile/chemistry/*therapeutic use Volatile Organic Compounds/chemistry/*therapeutic use;"
Notes:		"MedlineMaggio, Antonella Rosselli, Sergio Bruno, Maurizio eng Review United Arab Emirates 2016/06/10 Curr Pharm Des. 2016; 22(26):4011-27. doi: 10.2174/1381612822666160607065917"