| Title: | Cerumenogram: a new frontier in cancer diagnosis in humans |
| Author(s): | Barbosa JMG; Pereira NZ; David LC; de Oliveira CG; Soares MFG; Avelino MAG; de Oliveira AE; Shokry E; Filho NRA; |
| Address: | "Laboratory of Extraction and Separation Methods (LAMES), Institute of Chemistry, Federal University of Goias (UFG), Campus II - Samambaia, 74690-900, Goiania, GO, Brazil. joaomarcosquim.ufg@outlook.com. Laboratory of Extraction and Separation Methods (LAMES), Institute of Chemistry, Federal University of Goias (UFG), Campus II - Samambaia, 74690-900, Goiania, GO, Brazil. Clinical Hospital, Federal University of Goias (UFG), Campus I - Colemar Natal e Silva, 74605-020, Goiania, GO, Brazil. Laboratory of Theoretical and Computational Chemistry (LQTC), Institute of Chemistry, Federal University of Goias (UFG), Campus II - Samambaia, 74690-970, Goiania, GO, Brazil. Laboratory of Extraction and Separation Methods (LAMES), Institute of Chemistry, Federal University of Goias (UFG), Campus II - Samambaia, 74690-900, Goiania, GO, Brazil. nelsonroberto@ufg.br" |
| DOI: | 10.1038/s41598-019-48121-4 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate" |
| Keywords: | "*Biomarkers Case-Control Studies Cerumen/*metabolism Gas Chromatography-Mass Spectrometry/methods Humans Magnetic Resonance Imaging/methods Metabolomics/*methods Neoplasms/*diagnosis/etiology/*metabolism Tomography, X-Ray Computed/methods Volatile Organic;" |
| Notes: | "MedlineBarbosa, Joao Marcos Goncalves Pereira, Naiara Zedes David, Lurian Caetano de Oliveira, Camilla Gabriela Soares, Marina Ferraz Gontijo Avelino, Melissa Ameloti Gomes de Oliveira, Anselmo Elcana Shokry, Engy Filho, Nelson Roberto Antoniosi eng Research Support, Non-U.S. Gov't England 2019/08/15 Sci Rep. 2019 Aug 13; 9(1):11722. doi: 10.1038/s41598-019-48121-4" |
